Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Seeds grant vision to your team.
Placing a seed in your spell's path after you have cast it gives you the best chance of having a seed in the proper spot.
Zyra is a great ambusher - look for opportunities to set a trap of seeds in brush, then lure enemies in.
The Karthus Zyra synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Zyra, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Zyra. His KDA fell from NaN to NaN. This negative change shows that Zyra helps Karthus perform poorer in ranked League of Legends games. Yet, the small difference proves that this performance change is only marginal.
When Karthus plays on the same team as Zyra, he observes a marginal improvement in his complete damage output. This could indicate that Zyra provides protection for him to dish out more damage or that her presence on the team also helps extend the round's duration. Similarly, when Karthus is played alongside Zyra on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Zyra.
Moreover, when Karthus plays with Zyra on the same team, he usually takes a little more damage than when he plays alone. Receiving more damage may mean that Zyra does a poor job of protecting Karthus in teamfights.
There is no one best synergy for Karthus that will always be his ideal ally. Yet, overall, Zyra is a great ally for Karthus. By being on the same team as Karthus, she improves their win rate by 4.2% to 51.5%. This shows that there is an important synergy between Karthus and Zyra that allows them to perform stronger together than alone.
Zyra has a lower difficulty than Karthus. That means Karthus players don't need to be cautious when enlisting Zyra allies to fight alongside, as they will need a relatively low level of skill to be able to work well with you.
Working together, Karthus players will likely observe an overall large increase in your team’s capability to deal magic damage. Together, these champions are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Karthus and Zyra together, you may not be giving your side much tankyness. Make sure to bring other champs on your team that neutralizes this relative disparity in this pairing's kit.
Regardless of your Zyra ally's skill level, you should focus on increasing your gold income, outlasting your enemies, and clearing objectives. If you do this, you will do well, regardless.
If you would like to learn all of the intricacies of Karthus in order to work well with Zyra during both the lane and mid / late game phases of League of Legends rounds, you should keep reading to gather additional lessons on this champion pairing. If you mind the build and suggestions shown here, you will increase your win rate by a lot.
The most important finished items to focus on in your Karthus and Zyra synergy build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus combined at least these three finished items in his build, he performed significantly better when fighting alongside Zyra than with most other commonly used item sets. In fact, Karthus boasted an average winrate of 51.5% when synergizing his build and playstyle to Zyra with this build.
To have the best likelihood of crushing your oponents, you should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the runes players chose for this champion pairing, this sequence of runes yielded the best win rate. Notably, these runes provided a 51.5% win rate overall.
If you want to get Karthus and Zyra synergy tips and builds for a an individual skill level, feel free to select one from the selection menu provided above. At first, the stats and strategies displayed are calculated using all rounds run with these champions.