Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Sleepy Trouble Bubble travels further over walls. Find a hiding spot to set up for a long distance kill.
Break Sleep with your biggest damage source, since enemies who are asleep take double damage.
Paddle Star deals more damage the further it has flown. Casting it behind yourself before redirecting can deal tons of damage.
The Karthus Zoe synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Zoe, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Zoe. His KDA decreased from NaN to NaN. This decrease shows that Zoe helps Karthus perform not as well in competitive League of Legends games. Yet, the small difference proves that this performance change is not very impactful.
When Karthus is an ally to Zoe, he gets a little drop in his total damage output. This could signal that Zoe doesn't help protection for him to dish out more damage or that her participation also helps extend the round's duration. Similarly, when Karthus is played alongside Zoe on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Zoe.
Additionally, when Karthus plays with Zoe on the same team, he usually takes a little more damage than when he plays alone. Taking more damage may indicate that Zoe does a poor job of protecting Karthus in teamfights.
There is no top synergy for Karthus that will no matter what be his top synergy. Yet, Zoe is a very typical ally for Karthus. By locking into the same side as Karthus, she decreases their win rate by -0.9% to 46.4%. This demonstrates that there is only a small bond between Karthus and Zoe that allows them to perform not as well together than without each other.
Zoe has a lower difficulty than Karthus. That means you don't need to be careful when enlisting Zoe allies to go into battle on the same side as, as they will require a relatively low level of skill to do well with you.
Fighting on the same side, you will likely see an overall large increase in your team’s capacity to deal magical damage. When paired, these champions can deal quite a lot of AP type damage.
Although, by pairing Karthus and Zoe together, you may not be giving your other allies a great deal of anti-tank damage dealing potential. Make sure to include other champions on your team that helps cover this relative gap in this pairing's kit.
Regardless of the skill of your Zoe ally, you need to focus on maximizing your income, staying alive by avoiding foolish fights, and clearing objectives. If you do this, you should do well anyway.
If you would like to learn all of the intricacies of Karthus in order to pair well with Zoe during both the lane and mid / late game phases of LoL matches, you should continue reading to pick up a few extra tips and tricks for this champion pairing. If you listen to the build and suggestions shown above, you will increase your win rate by a lot.
The most important items to prioritize in your Karthus and Zoe synergy build include Rabadon's Deathcap, Malignance, and Shadowflame. When Karthus included at least these three finished items in his build, he did significantly better when paired up with Zoe than with many other commonly used item sets. In fact, Karthus had an average winrate of 46.4% helping carry Zoe with these items in his kit.
To have the highest likelihood of defeating your oponents, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Of all the runes we have analyed for Karthus and Zoe pairings, this set of runes yielded the top win rate. Moreover, these runes gave a 46.4% winrate overall.
By default, tips, stats, and builds on how to team up Zoe with Karthus are displayed for all ranked divisions combined. To filter the stats and builds to a specific rank, you should use the selection menu located at the top of this page.