Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Time Warp is an effective way to enable allies to finish off enemies, or escape from a losing battle.
Chronoshift is a powerful deterrent to attacking your carries, but casting Chronoshift too early in a fight can cause the enemy to switch targets too soon, making it less effective.
You can combine the use of Time Bomb and Rewind to place two Time Bombs on a target quickly. Placing the second bomb will detonate the first and stun all nearby enemies.
The Karthus Zilean synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Zilean, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Zilean. His KDA fell from NaN to NaN. This decrease shows that Zilean helps Karthus perform poorer in competitive LoL rounds. Yet, the small difference shows that this performance change is not very impactful.
When Karthus tries to synergize with Zilean, he gets a small increase in his complete damage output. This difference could indicate that Zilean provides protection for him to deal more damage or that his presence on the team also helps extend the game's duration. Similarly, when Karthus is played with Zilean on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Zilean.
Moreover, when Karthus plays with Zilean on the same team, he typically receives more damage than when he plays alone. Getting dealt more damage may mean that Zilean does a poor job of covering Karthus during teamfights.
There is no universally accepted best ally for Karthus that will 100% of the time be his #1 synergy. Yet, overall, Zilean is a terrible teammate for Karthus. By playing on the same side as Karthus, he drops their win rate by -3.8% to 43.5%. This demonstrates that there is a terrible synergy between Karthus and Zilean that results in them performing worse together than without each other.
Zilean has a lower difficulty than Karthus. That means you don't need to be very careful when enlisting Zilean allies to go into battle on the same side as, as they will require a lower level of skill to be able to work well with you.
Fighting alongside, you should expect to witness an overall large increase in your team’s capacity to to do a lot of AP damage. Combined, these champs are able to dish out a surprising amount of magic type damage.
In contrast, by aligning Karthus and Zilean together, you probably will not be providing your side enough sustained damage output. Plan to include other champions on your team that nullifies this gap in this pairing's kit.
Regardless of your Zilean ally's ability, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Karthus to synergize with Zilean during both the early game and mid / late game phases of LoL rounds, you should continue reading to learn additional lessons on this champion pairing. If you use the build and suggestions presented here, you will grow your win rate by a lot.
The top items to have in your Karthus and Zilean synergy build include Malignance, Stormsurge, and Liandry's Torment. When Karthus bought at least these three pieces in his build, he did significantly better as an ally of Zilean than with many other common item sets. In fact, Karthus had an average winrate of 43.5% when synergizing his build and playstyle to Zilean with this build.
To have the greatest probability of defeating your oponents, you should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune builds that we analyzed for this team composition, this composite of runes resulted in the greatest win rate. In fact, these runes gave a 43.5% winrate overall.
By default, tips, statistics, and builds on how to synergize Zilean with Karthus are presented for all skill levels, merged. If you want to scope the statistics and builds to a distinct rank, you may use the selection menu located above.