Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Placing a Living Shadow before using Death Mark can give Zed a safe escape from combat.
Saving energy and spell cooldowns until you use your ultimate will maximize Death Mark's damage.
Quickly double tapping Living Shadow will teleport Zed to his shadow immediately for rapid escapes.
The Karthus Zed synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Zed, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Zed. His KDA went down from NaN to NaN. This worsening shows that Zed helps Karthus perform worse in ranked League rounds. Yet, the small difference proves that this performance change is only marginal.
When Karthus tries to synergize with Zed, he gets a little increase in his total damage dealt. This change may signal that Zed supports by providing protection for him to deal more damage or that his presence also helps extend the round's duration. Similarly, when Karthus is played alongside Zed on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Zed.
Additionally, when Karthus plays with Zed on the same side, he typically receives a little more damage than when he plays alone. Taking more damage could indicate that Zed does a poor job of covering Karthus in teamfights.
There is no perfect companion for Karthus that will always be his #1 synergy. Yet, Zed is a very typical teammate for Karthus. By playing on the same side as Karthus, he increases their win rate by 0.7% to 48.0%. This clearly indicates that there is only a small strategic relationship between Karthus and Zed that results in them performing stronger together than alone.
Zed has a lower difficulty than Karthus. That means Karthus players don't need to be very careful when lining up Zed teammates to go into battle on the same side as, as they will need a relatively low level of skill to play well with you.
Working on the same side, Karthus players should expect to observe an overall large increase in your team’s ability to deal physical damage. Combined, these two can tear through the other team with a lot of physcial damage.
Although, by bringing Karthus and Zed together, you will not be giving your team a great deal of protection for burst damage. Plan to include other champions on your team that offsets this relative disparity in this pairing's abilities.
Regardless of the skill of your Zed ally, you should focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well, regardless.
To truly master Karthus to synergize with Zed during both the early game and mid / late game phases of League of Legends matches, you should continue reading to gather some more tips and tricks for this champion pairing. If you listen to the build and tips shown above, you should grow your win rate significantly.
The top items to prioritize in your Karthus and Zed synergy build consist of Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus included at least these three finished items in his build, he performed a lot better as an ally of Zed than with most other commonly used builds. In fact, Karthus boasted an average win rate of 48.0% when playing alongside Zed with this build.
To have the best chance of coming out on top against your oponents, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the runes players chose for this team composition, this order of runes resulted in the top win rate. Moreover, these runes averaged a 48.0% winrate overall.
If you need to get Karthus and Zed synergy tips and stats for a a specific skill level, feel free to select one from the selection menu provided above. At first, the stats and strategies shown are computed using all matches with data with these champions.