Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Be very careful about when to use Life Form Disintegration Ray. Many champions have abilities that can interrupt the spell.
Shooting Plasma Fission diagonally and splitting at maximum range allows you to hit opponents that are out of the range of the initial missile, but is more challenging to pull off.
When laning, use Void Rift to kill minions while building stacks of Organic Deconstruction on your opponent. You can then follow up with your other abilities.
The Karthus Vel'Koz synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vel'Koz, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Vel'Koz. His KDA decreased from NaN to NaN. This fall shows that Vel'Koz helps Karthus perform poorer in ranked League matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus plays on the same team as Vel'Koz, he gets a little decrease in his full damage output. This difference may indicate that Vel'Koz does not support by providing protection for him to dish out more damage or that his participation also helps extend the game's duration. Similarly, when Karthus is played alongside Vel'Koz on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Vel'Koz.
Moreover, when Karthus plays with Vel'Koz on the same side, he usually receives a little more damage than when he plays alone. Taking more damage could indicate that Vel'Koz does a poor job of protecting Karthus during team fights.
There is no one best synergy for Karthus that will always be his #1 ally. However, overall, Vel'Koz is a not very good ally for Karthus. By being on the same team as Karthus, he lowers their win rate by -1.5% to 45.8%. This proves that there is a negative bond between Karthus and Vel'Koz that allows them to perform worse together than alone.
Vel'Koz has a greater difficulty than Karthus. That means you should be careful when finding Vel'Koz comrades to go into battle on the same side as, as they will require a greater level of skill to play well with you.
When playing together, Karthus players will likely observe an overall large increase in your team’s capacity to deal magic damage. Combined, these champs are able to dish out a surprising amount of magic type damage.
Although, by aligning Karthus and Vel'Koz together, you probably will not be providing your side a great deal of AD. Make sure to pick other champions on your team that offsets this relative gap in this pairing's playstyle.
Regardless of the ability of your Vel'Koz ally, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you follow these simple suggestions, you should do well anyway.
To learn all of the intricacies of Karthus in order to pair well with Vel'Koz during both the laning and mid / late game phases of League of Legends games, you should continue reading to master some more tips and tricks for this champion pairing. If you listen to the build and suggestions shown above, you will increase your win rate significantly.
The ideal items to have in your Karthus and Vel'Koz synergy build include Rabadon's Deathcap, Malignance, and Shadowflame. When Karthus included at least these three items in his build, he performed significantly better when fighting alongside Vel'Koz than with most other commonly used item sets. In fact, Karthus had an average win rate of 45.8% when synergizing his build and playstyle to Vel'Koz with these items in his kit.
To have the best probability of beating your oponents, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune sets players picked for Karthus and Vel'Koz pairings, this blending of runes resulted in the best win rate. Moreover, these runes gave a 45.8% winrate overall.
If you need to get Karthus and Vel'Koz synergy tips and stats for a a particular division, please choose one from the selection menu displayed above. By default, the statistics and strategies shown are computed using all games run with these champions.