Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Try to take advantage of Piercing Arrow's very long range to snipe at enemy champions before a fight or as they're trying to flee.
An early point in Blighted Quiver helps harass enemy champions and get killing blows on minions.
During short range fights it's sometimes best to fire Piercing Arrow quickly, rather than charging it to full power.
The Karthus Varus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Varus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Varus. His KDA decreased from NaN to NaN. This decrease shows that Varus helps Karthus perform poorer in competitive League matches. Yet, the small difference proves that this performance change is only marginal.
When Karthus is paired with Varus, he sees a little decrease in his total damage output. This difference may signal that Varus does not support by providing cover for him to dish out more damage or that his presence also helps extend the round's duration. Similarly, when Karthus is played alongside Varus on the same side, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Varus.
Moreover, when Karthus plays with Varus on the same side, he often takes a little more damage than when he plays alone. Taking more damage could mean that Varus does a poor job of protecting Karthus during teamfights.
There is no top companion for Karthus that will always be his ideal ally. However, overall, Varus is a not very good teammate for Karthus. By locking into the same team as Karthus, he drops their win rate by -2.8% to 44.5%. This signals that there is a harmful bond between Karthus and Varus that allows them to perform worse together than without each other.
Varus has a much lower diffuclty than Karthus. That means Karthus players don't need to be cautious when enlisting Varus comrades to play with, as they will have to have a much lower level of skill to be able to work well with you.
Working alongside, you should expect to see an overall large increase in your team’s capacity to deal magic damage. Combined, these champions are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Karthus and Varus together, you may not be giving your side a lot of engage potential. Make sure to bring other champions on your team that nullifies this relative hole in this pairing's playstyle.
Regardless of your Varus ally's skill level, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well anyway.
If you would like to learn all of the intricacies of Karthus in order to pair well with Varus during both the early game and mid / late game phases of League games, you should continue reading to master some more tricks and insights into this champion pairing. If you pay attention to the build and stats shown above, you should increase your win rate by a lot.
The most important items to focus on in your Karthus and Varus synergy build include Rabadon's Deathcap, Malignance, and Void Staff. When Karthus incorporated at least these three great items in his build, he performed significantly better as an ally of Varus than with many other typical item sets. In fact, Karthus had an average winrate of 44.5% when synergizing his build and playstyle to Varus with these items in his kit.
To have the best chance of beating your oponents, Karthus players should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune combinations players used for this champion pairing, this combination of runes resulted in the greatest win rate. Notably, these runes gave a 44.5% winrate overall.
If you need to see Karthus and Varus cooperations tips and stats for a a distinct rank, feel free to choose one from the selection menu displayed above. At first, the statistics and tips and suggestions shown are computed using every round completed with these champions.