Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The Karthus Twitch synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Twitch, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Twitch. His KDA decreased from NaN to NaN. This fall shows that Twitch helps Karthus perform worse in competitive League matches. Yet, the small difference indicates that this performance change is not very impactful.
When Karthus tries to synergize with Twitch, he sees a small decrease in his full damage output. This could signal that Twitch does not provide cover for him to deal more damage or that his allyship also helps extend the round's duration. Similarly, when Karthus is played together with Twitch on the same side, he usually scores many fewer killing sprees than when he plays without Twitch. This is contrasting evidence that he is worse when playing synergisticly with Twitch.
Additionally, when Karthus plays with Twitch on the same side, he often receives more damage than when he fights alone. Taking more damage could mean that Twitch does a poor job of protecting Karthus during team fights.
There is no ideal champion pairing for Karthus that will 100% of the time be his ideal teammate. Yet, overall, Twitch is a very typical teammate for Karthus. By being on the same side as Karthus, he raises their win rate by 0.9% to 48.2%. This demonstrates that there is a weak bond between Karthus and Twitch that allows them to perform at the top of their game together than alone.
Twitch has a lower difficulty than Karthus. That means you don't need to be careful when lining up Twitch comrades to fight alongside, as they will require a lower level of skill to be able to do well with you.
When playing on the same side, Karthus players should expect to observe an overall large increase in your team’s capability to deal magical damage. Combined, these two can deal quite a lot of AP type damage.
Although, by grouping Karthus and Twitch together, you probably will not be granting your side very much protection for burst damage. We recommend you bring other champs on your team that fills this disparity in this pairing's potential.
Regardless of the ability of your Twitch teammate, you should focus on increasing your income, outlasting your enemies, and taking down objectives. If you do this, you will do well, regardless.
If you would like to truly master Karthus to synergize with Twitch during both the laning and mid / late game phases of League of Legends, you should keep reading to master a few extra tips and tricks for this champion pairing. If you listen to the build and suggestions displayed here, you will increase your win rate by a lot.
The top finished items to have in your Karthus and Twitch synergy build consist of Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus combined at least these three great items in his build, he did significantly better when fighting alongside Twitch than with most other common builds. In fact, Karthus boasted an average winrate of 48.2% helping carry Twitch with these items in his kit.
To have the greatest likelihood of crushing your oponents, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players picked for this team composition, this mixture of runes yielded the best win rate. In fact, these runes averaged a 48.2% winrate overall.
If you want to see Karthus with Twitch collaboration tips and stats for a an individual rank, feel free to select one from the selection menu shown above. By default, the stats and strategies shown are computed using every match completed with both champs.