Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Twisted Fate is viable as an Attack Damage or Ability Power character, letting him fit on many different team compositions.
Stealth characters often escape a battle with very low hit points. Take advantage of Destiny's ability to reveal stealthed units to finish them off.
Coordinate with your allies for the best time to use Destiny to ambush enemies.
The Karthus Twisted Fate synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Twisted Fate, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Twisted Fate. His KDA worsened from NaN to NaN. This decrease shows that Twisted Fate helps Karthus perform worse in ranked League matches. Yet, the small difference shows that this performance change is not very impactful.
When Karthus is an ally to Twisted Fate, he gets a little decrease in his full damage output. This could indicate that Twisted Fate does not help protection for him to dish out more damage or that his support also helps increase the round's duration. Similarly, when Karthus is played together with Twisted Fate on the same team, he usually scores many fewer killing sprees compared to when he plays without Twisted Fate. This is contrasting evidence that he is worse when playing synergisticly with Twisted Fate.
Moreover, when Karthus plays with Twisted Fate on the same side, he often takes a little more damage than when he plays alone. Taking more damage could indicate that Twisted Fate does a poor job of protecting Karthus during teamfights.
There is no perfect synergy for Karthus that will no matter what be his #1 teammate. Yet, overall, Twisted Fate is a very typical companion for Karthus. By playing on the same team as Karthus, he decreases their win rate by -0.1% to 47.2%. This proves that there is only a small synergy between Karthus and Twisted Fate that results in them performing not as well together than without each other.
Twisted Fate has a greater difficulty than Karthus. That means you should be cautious when enlisting Twisted Fate comrades to fight alongside, as they will need a greater level of skill to do well with you.
Working alongside, Karthus players will likely observe an overall large increase in your team’s capability to deal magical damage. Together, these champs are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Karthus and Twisted Fate together, you probably will not be providing your other allies enough engage potential. Plan to bring other champs on your team that nullifies this relative disparity in their potential.
Regardless of the ability of your Twisted Fate ally, you should focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well anyway.
To learn all of the intricacies of Karthus to pair well with Twisted Fate during both the laning and mid / late game phases of League of Legends, you should continue reading to learn some more tricks and insights into this champion pairing. If you pay attention to the build and tips displayed above, you will grow your win rate by a lot.
The top items to get in your Karthus and Twisted Fate synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus combined at least these three pieces in his build, he did significantly better when fighting alongside Twisted Fate than with many other common builds. In fact, Karthus boasted an average win rate of 47.2% when synergizing his build and playstyle to Twisted Fate with this build.
To have the highest likelihood of defeating your oponents, Karthus players should use the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Of all the runes we have analyed for this team composition, this mix of runes resulted in the highest win rate. Notably, these runes averaged a 47.2% win rate overall.
By default, tips, statistics, and builds on how to pair Twisted Fate with Karthus are presented for every ranked division. To scope the stats and builds to a particular player tier, you should use the selection menu earlier in the counter matchup guide.