Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
To maximize your ultimate's damage use it when there are many spheres on the battlefield.
After you hit an enemy champion with Force of Will follow up with Dark Sphere, they'll be slowed and have a hard time avoiding it.
Get one of your spells to rank 5 as quickly as possible, they gain powerful bonus effects at max rank.
The Karthus Syndra synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Syndra, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Syndra. His KDA fell from NaN to NaN. This worsening shows that Syndra helps Karthus perform poorer in competitive League of Legends rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus plays on the same team as Syndra, he observes a little drop in his total damage output. This change could signal that Syndra does not help cover for him to dish out more damage or that her presence on the team also helps increase the round's duration. Similarly, when Karthus is played alongside Syndra on the same side, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Syndra.
Moreover, when Karthus plays with Syndra on the same team, he usually takes more damage than when he fights alone. Getting dealt more damage may mean that Syndra does a poor job of protecting Karthus during team fights.
There is no one best synergy for Karthus that will no matter what be his top ally. However, overall, Syndra is a terrible teammate for Karthus. By playing on the same side as Karthus, she lowers their win rate by -4.9% to 42.4%. This clearly indicates that there is a very bad bond between Karthus and Syndra that allows them to perform worse together than alone.
Syndra has a greater difficulty than Karthus. That means you must be very careful when lining up Syndra allies to play with, as they will have to have a greater level of skill to be able to work well with you.
When playing alongside, Karthus players should expect to observe an overall large increase in your team’s capacity to deal magic damage. Combined, these champs are able to dish out a surprising amount of magic type damage.
Although, by bringing Karthus and Syndra together, you will not be granting your other allies enough sustained damage output. We recommend you include other champions on your team that offsets this disparity in this pairing's capabilities.
Regardless of your Syndra ally's ability, you need to focus on maximizing your income, staying alive by avoiding foolish fights, and clearing objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Karthus to work well with Syndra during both the early game and mid / late game phases of LoL rounds, you should continue reading to master some more tricks and insights into this champion pairing. If you use the build and stats displayed above, you will grow your win rate significantly.
The ideal items to include in your Karthus and Syndra synergy build include Rabadon's Deathcap, Shadowflame, and Liandry's Torment. When Karthus incorporated at least these three pieces in his build, he did a lot better when fighting alongside Syndra than with many other typical item sets. In fact, Karthus had an average win rate of 42.4% when playing alongside Syndra with these items in his kit.
To have the best likelihood of annihilating your oponents, Karthus players should use the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune sets we have analyed for this team composition, this combination of runes yielded the best win rate. In fact, these runes provided a 42.4% win rate overall.
If you need to see Karthus and Syndra synergy tips and stats for a an individual division rank, please select one from the selection menu shown above. At first, the statistics and strategies shown are calculated using every game finished with both champions.