Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Karthus Sett synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Sett, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Sett. His KDA decreased from NaN to NaN. This drop shows that Sett helps Karthus perform poorer in ranked League of Legends games. Yet, the small difference indicates that this performance change is only marginal.
When Karthus is paired with Sett, he observes a little increase in his complete damage dealt. This may demonstrate that Sett provides protection for him to deal more damage or that his participation also helps increase the match's duration. Similarly, when Karthus is played with Sett on the same team, he usually scores many fewer killing sprees than when he plays without Sett. This is contrasting evidence that he is worse when playing synergisticly with Sett.
Additionally, when Karthus plays with Sett on the same team, he usually receives a little more damage than when he plays alone. Taking more damage may mean that Sett does a poor job of covering Karthus in teamfights.
There is no one best champion pairing for Karthus that will 100% of the time be his #1 ally. Yet, Sett is a decent ally for Karthus. By locking into the same team as Karthus, he increases their win rate by 2.0% to 49.3%. This demonstrates that there is pretty good bond between Karthus and Sett that results in them performing at the top of their game together than alone.
Sett has a much lower diffuclty than Karthus. That means you don't need to be careful when lining up Sett comrades to go into battle on the same side as, as they will require a much lower level of skill to be able to work well with you.
Fighting together, you should see an overall large increase in your team’s ability to deal magic damage. Together, these champs can blast through enemies with magic damage.
Conversely, by bringing Karthus and Sett together, you probably will not be providing your team a lot of crowd control. Plan to bring other champs on your team that offsets this relative hole in this pairing's playstyle.
Regardless of the skill of your Sett teammate, you need to focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you do this, you should do well, regardless.
To truly master Karthus in order to pair well with Sett during both the laning and mid / late game phases of League matches, you should continue reading to master a few extra tips and tricks for this champion pairing. If you mind the build and tips displayed above, you should increase your win rate significantly.
The best finished items to have in your Karthus and Sett synergy build include Rabadon's Deathcap, Shadowflame, and Stormsurge. When Karthus bought at least these three pieces in his build, he did a lot better when paired up with Sett than with most other typical item sets. In fact, Karthus had an average win rate of 49.3% when synergizing his build and playstyle to Sett with these items in his kit.
To have the greatest probability of vanquishing your oponents, Karthus players should take the Dark Harvest, Cheap Shot, Eyeball Collection, Treasure Hunter, Coup de Grace, and Presence of Mind runes from the Domination and Precision rune sets. Of all the rune combinations players chose for Karthus and Sett pairings, this mix of runes resulted in the greatest win rate. Moreover, these runes gave a 49.3% winrate overall.
If you need to view Karthus and Sett collaboration tips and stats for a a distinct player tier, feel free to choose one from the selection menu displayed above. If viewing for the first time, the statistics and tips and suggestions given are calculated using every round with data with both champions.