Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Karthus Seraphine synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Seraphine, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Seraphine. His KDA fell from NaN to NaN. This drop shows that Seraphine helps Karthus perform not as well in competitive LoL games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus is paired with Seraphine, he gets a marginal improvement in his total damage dealt. This could indicate that Seraphine provides protection for him to deal more damage or that her support also helps increase the game's duration. Similarly, when Karthus is played alongside Seraphine on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Seraphine.
Moreover, when Karthus plays with Seraphine on the same side, he typically takes a little more damage than when he fights alone. Taking more damage could indicate that Seraphine does a poor job of protecting Karthus during teamfights.
There is no universally accepted best companion for Karthus that will 100% of the time be his #1 teammate. Yet, overall, Seraphine is a very typical teammate for Karthus. By playing on the same team as Karthus, she drops their win rate by -0.8% to 46.5%. This clearly indicates that there is not really a strong bond between Karthus and Seraphine that results in them performing worse together than without each other.
Seraphine has a much lower diffuclty than Karthus. That means Karthus players don't need to be careful when finding Seraphine allies to play with, as they will need a much lower level of skill to be able to cooperate well with you.
Playing cooperatively, you will likely observe an overall large increase in your team’s capacity to buff allies and debuff enemies. Together, these two should be able to manipulate the pace of team fights.
In contrast, by pairing Karthus and Seraphine together, you probably will not be giving your team much attack damage. We recommend you include other champs on your team that nullifies this gap in their kit.
Regardless of your Seraphine ally's ability, you need to focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well, regardless.
To truly master Karthus to work well with Seraphine during both the lane and mid / late game phases of League, you should keep reading to pick up some more lessons on this champion pairing. If you pay attention to the build and stats shown here, you will grow your win rate by a lot.
The most important finished items to use in your Karthus and Seraphine synergy build include Malignance, Void Staff, and Shadowflame. When Karthus bought at least these three pieces in his build, he did significantly better when fighting alongside Seraphine than with many other commonly used item sets. In fact, Karthus boasted an average win rate of 46.5% helping carry Seraphine with these items in his kit.
To have the best likelihood of crushing your oponents, Karthus players should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the runes players picked for Karthus and Seraphine pairings, this composite of runes resulted in the highest win rate. Notably, these runes gave a 46.5% win rate overall.
If you need to get Karthus with Seraphine collaboration tips and stats for a a specific division rank, please choose one from the selection menu above. By default, the stats and strategies displayed are computed using every match completed with both champs.