Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Use Overload's passive to optimize for maximum damage or maximum speed.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
The Karthus Ryze synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Ryze, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Ryze. His KDA went down from NaN to NaN. This decrease shows that Ryze helps Karthus perform not as well in competitive League of Legends rounds. Yet, the small difference indicates that this performance change is not very impactful.
When Karthus tries to synergize with Ryze, he sees a small decrease in his total damage output. This difference may demonstrate that Ryze does not support by providing protection for him to dish out more damage or that his allyship also helps extend the match's duration. Similarly, when Karthus is played together with Ryze on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Ryze.
Moreover, when Karthus plays with Ryze on the same team, he typically takes a little more damage than when he fights alone. Taking more damage could mean that Ryze does a poor job of protecting Karthus in team fights.
There is no one best synergy for Karthus that will 100% of the time be his ideal ally. However, Ryze is a very bad ally for Karthus. By locking into the same team as Karthus, he lowers their win rate by -6.2% to 41.1%. This shows that there is a very bad bond between Karthus and Ryze that results in them performing not as well together than alone.
Ryze has a lower difficulty than Karthus. That means Karthus players don't need to be cautious when finding Ryze comrades to go into battle on the same side as, as they will have to have a relatively low level of skill to be able to play well with you.
Fighting alongside, Karthus players should observe an overall large increase in your team’s capability to deal magic damage. When paired, these two can deal quite a lot of AP type damage.
Conversely, by pairing Karthus and Ryze together, you probably will not be providing your other allies a great deal of attack damage. Make sure to have other champs on your team that helps cover this relative hole in this pairing's capabilities.
Regardless of your Ryze ally's ability, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you do this, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus to work well with Ryze during both the laning and mid / late game phases of League, you should continue reading to gather a few extra tips and tricks for this champion pairing. If you pay attention to the build and suggestions shown above, you will increase your win rate significantly.
The ideal items to get in your Karthus and Ryze synergy build consist of Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus used at least these three items in his build, he did much better as an ally of Ryze than with many other typical builds. In fact, Karthus had an average win rate of 41.1% when playing alongside Ryze with this build.
To have the highest likelihood of vanquishing your oponents, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the runes players used for this team composition, this blending of runes resulted in the best win rate. In fact, these runes averaged a 41.1% win rate overall.
By default, tips, statistics, and builds on how to pair Ryze with Karthus are given for all skill levels combined. To filter the statistics and builds to a particular skill level, you should use the selection menu located earlier on the page.