Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Tap version of Bone Skewer is much faster and deals additional damage.
A lot of your agressive spells are also your escapes. Make sure you always have a plan to get out of the fight.
Hitting an enemy with the Hold version of Bone Skewer will always pull them the same distance. Use it in melee range to throw targets behind you.
Pyke is very fragile so don't be afraid to temporarily run from a fight. You can regenerate a significant amount of health from Gift of the Drowned Ones when enemies can't see you.
The Karthus Pyke synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Pyke, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Pyke. His KDA fell from NaN to NaN. This drop shows that Pyke helps Karthus perform worse in competitive League matches. Yet, the small difference indicates that this performance change is only marginal.
When Karthus tries to synergize with Pyke, he gets a small increase in his complete damage output. This change could demonstrate that Pyke provides cover for him to dish out more damage or that his allyship also helps extend the match's duration. Similarly, when Karthus is played together with Pyke on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Pyke.
Moreover, when Karthus plays with Pyke on the same team, he usually receives a little less damage than when he fights alone. Getting dealt not as much damage may indicate that Pyke does a decent job of covering Karthus during team fights.
There is no ideal champion pairing for Karthus that will always be his #1 ally. Yet, overall, Pyke is a good companion for Karthus. By being on the same team as Karthus, he raises their win rate by 1.0% to 48.3%. This clearly indicates that there is pretty good synergy between Karthus and Pyke that allows them to perform stronger together than without each other.
Pyke has a lower difficulty than Karthus. That means you don't need to be careful when enlisting Pyke allies to fight alongside, as they will have to have a relatively low level of skill to be able to cooperate well with you.
Playing together, you will likely see an overall large increase in your team’s ability to deal physical damage. Combined, these two can tear through the other team with a lot of physcial damage.
Conversely, by grouping Karthus and Pyke together, you may not be granting your other allies very much cover. Plan to include other champions on your team that nullifies this hole in their abilities.
Regardless of your Pyke ally's skill level, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you do this, you should do well, regardless.
If you would like to truly master Karthus in order to work well with Pyke during both the early game and mid / late game phases of League matches, you should continue reading to learn a few extra tricks and insights into this champion pairing. If you listen to the build and suggestions presented above, you will increase your win rate by a lot.
The most crucial finished items to build first in your Karthus and Pyke synergy build include Rabadon's Deathcap, Shadowflame, and Liandry's Torment. When Karthus used at least these three pieces in his build, he did a lot better when paired up with Pyke than with most other common item sets. In fact, Karthus had an average win rate of 48.3% when playing alongside Pyke with this build.
To have the best likelihood of annihilating your oponents, Karthus players should take the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Out of all the runes players used for this team composition, this mix of runes yielded the best win rate. In fact, these runes averaged a 48.3% win rate overall.
By default, tips, statistics, and builds on how to pair Pyke with Karthus are shown for every ranked division. To filter the statistics and builds to an individual division, you should use the selection menu located earlier on the page.