Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Mortal Will activates after 5 spells or basic attacks - plan your way through fights to allow you to activate it more than once.
Whittle the enemy down with Comet Spears before you jump in.
If an enemy is going to get out of range of your Aegis Assault, you can recast the spell to immediately fire the shield slam.
The Karthus Pantheon synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Pantheon, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Pantheon. His KDA decreased from NaN to NaN. This fall shows that Pantheon helps Karthus perform poorer in ranked LoL rounds. Yet, the small difference shows that this performance change is not very impactful.
When Karthus tries to synergize with Pantheon, he sees a small increase in his total damage dealt. This could demonstrate that Pantheon helps provide protection for him to deal more damage or that his participation also helps increase the match's duration. Similarly, when Karthus is played with Pantheon on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Pantheon.
Moreover, when Karthus plays with Pantheon on the same side, he usually receives a little more damage than when he plays alone. Taking more damage could indicate that Pantheon does a poor job of protecting Karthus in teamfights.
There is no universally accepted best companion for Karthus that will always be his best ally. Yet, overall, Pantheon is a pretty good teammate for Karthus. By playing on the same team as Karthus, he raises their win rate by 2.0% to 49.3%. This demonstrates that there is a somewhat important strategic relationship between Karthus and Pantheon that allows them to perform stronger together than alone.
Pantheon has a much lower diffuclty than Karthus. That means you don't need to be careful when enlisting Pantheon teammates to go into battle on the same side as, as they will require a much lower level of skill to do well with you.
Working on the same side, Karthus players should expect to observe an overall large increase in your team’s capability to deal magic damage. When paired, these champions can deal quite a lot of AP type damage.
In contrast, by pairing Karthus and Pantheon together, you may not be providing your other teammates a lot of cover. Plan to bring other champions on your team that offsets this disparity in their potential.
Regardless of your Pantheon ally's skill level, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Karthus to work well with Pantheon during both the laning and mid / late game phases of League of Legends games, you should keep reading to gather a few extra lessons on this champion pairing. If you listen to the build and stats shown above, you should grow your win rate by a lot.
The top finished items to focus on in your Karthus and Pantheon synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus included at least these three items in his build, he did significantly better when paired up with Pantheon than with most other typical builds. In fact, Karthus had an average winrate of 49.3% when playing alongside Pantheon with this build.
To have the highest chance of crushing your oponents, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune combinations that we analyzed for this team composition, this sequence of runes resulted in the greatest win rate. In fact, these runes gave a 49.3% win rate overall.
By default, tips, stats, and builds on how to pair Pantheon with Karthus are shown for all ranked divisions combined. If you would like to narrow the statistics and builds to a specific division, you can use the selection menu located at the top of this page.