Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Karthus Nilah synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Nilah, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Nilah. His KDA decreased from NaN to NaN. This drop shows that Nilah helps Karthus perform poorer in ranked LoL matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Karthus tries to synergize with Nilah, he observes a small decrease in his full damage output. This difference may indicate that Nilah does not help protection for him to deal more damage or that their presence also helps extend the match's duration. Similarly, when Karthus is played with Nilah on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing alongside Nilah.
Additionally, when Karthus plays with Nilah on the same team, he on average takes a little more damage than when he fights alone. Taking more damage may indicate that Nilah does a poor job of protecting Karthus in teamfights.
There is no top synergy for Karthus that will 100% of the time be his #1 synergy. However, Nilah is a good teammate for Karthus. By playing on the same team as Karthus, they increases their win rate by 2.9% to 50.2%. This clearly indicates that there is pretty good bond between Karthus and Nilah that results in them performing stronger together than without each other.
Nilah has a greater difficulty than Karthus. That means Karthus players should be very careful when arranging Nilah teammates to fight alongside, as they will need a greater level of skill to fight well with you.
When playing cooperatively, you should see an overall large increase in your team’s ability to deal magic damage. Together, these champions can deal quite a lot of AP type damage.
Although, by pairing Karthus and Nilah together, you will not be giving your other allies very much engage. Plan to bring other champs on your team that offsets this relative disparity in this pairing's playstyle.
Regardless of the ability of your Nilah ally, you need to focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus to work well with Nilah during both the lane and mid / late game phases of League of Legends, you should continue reading to learn additional tricks and insights into this champion pairing. If you mind the build and suggestions shown above, you should increase your win rate significantly.
The most crucial items to have in your Karthus and Nilah synergy build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus included at least these three great items in his build, he performed much better when paired up with Nilah than with most other common builds. In fact, Karthus boasted an average win rate of 50.2% when playing alongside Nilah with this build.
To have the greatest probability of coming out on top against your oponents, you should use the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune builds players used for Karthus and Nilah pairings, this sequence of runes yielded the highest win rate. In fact, these runes averaged a 50.2% win rate overall.
By default, tips, stats, and builds on how to synergize Nilah with Karthus are presented for all skill levels, merged. If you want to scope the statistics and builds to a particular rank, you can use the selection menu located earlier on the page.