Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
The Karthus Neeko synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Neeko, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Neeko. His KDA decreased from NaN to NaN. This negative change shows that Neeko helps Karthus perform worse in ranked League of Legends matches. Yet, the small difference indicates that this performance change is not very impactful.
When Karthus is paired with Neeko, he gets a barely noticable drop in his complete damage dealt. This may demonstrate that Neeko does not support by providing cover for him to deal more damage or that her allyship also helps increase the round's duration. Similarly, when Karthus is played alongside Neeko on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing alongside Neeko.
Additionally, when Karthus plays with Neeko on the same team, he usually takes a little more damage than when he plays alone. Getting dealt more damage could indicate that Neeko does a poor job of protecting Karthus during teamfights.
There is no perfect ally for Karthus that will no matter what be his #1 ally. Yet, Neeko is a very typical ally for Karthus. By being on the same team as Karthus, she lowers their win rate by -0.8% to 46.5%. This proves that there is a weak bond between Karthus and Neeko that results in them performing worse together than without each other.
Neeko has a lower difficulty than Karthus. That means you don't need to be careful when finding Neeko teammates to go into battle on the same side as, as they will have to have a lower level of skill to cooperate well with you.
Working alongside, Karthus players should witness an overall large increase in your team’s ability to to do a lot of AP damage. When paired, these champions can deal quite a lot of AP type damage.
Although, by grouping Karthus and Neeko together, you will not be providing your team enough anti-tank damage dealing potential. Make sure to have other champions on your team that fills this disparity in their abilities.
Regardless of the skill of your Neeko teammate, you need to focus on increasing your gold income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you will do well, regardless.
To truly master Karthus in order to synergize with Neeko during both the laning and mid / late game phases of LoL games, you should keep reading to learn additional tricks and insights into this champion pairing. If you listen to the build and stats presented above, you will grow your win rate by a lot.
The ideal items to use in your Karthus and Neeko synergy build include Rabadon's Deathcap, Shadowflame, and Liandry's Torment. When Karthus incorporated at least these three great items in his build, he performed a lot better as an ally of Neeko than with most other commonly used builds. In fact, Karthus had an average winrate of 46.5% when synergizing his build and playstyle to Neeko with these items in his kit.
To have the best likelihood of crushing your oponents, Karthus players should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune builds that we analyzed for Karthus and Neeko pairings, this composite of runes yielded the best win rate. Moreover, these runes averaged a 46.5% win rate overall.
If you need to see Karthus and Neeko synergy tips and builds for a an individual rank, please select one from the selection menu shown above. If viewing for the first time, the stats and tips and suggestions displayed are computed using every game run with these champs.