Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Paying attention to last hitting with Siphoning Strike will have a large impact at the end of a game.
If you're solo, Spirit Fire is a great way to farm a lane. It can be bad if you're in a lane with 2 and you push too far. Find the right balance between Siphoning Strike last hits and AoE farming.
If you have low defenses, people will focus you down even during your ultimate. Try buying some survivability items even in your DPS builds.
The Karthus Nasus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Nasus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Nasus. His KDA worsened from NaN to NaN. This fall shows that Nasus helps Karthus perform not as well in ranked LoL rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus is paired with Nasus, he gets a little drop in his total damage output. This change could signal that Nasus does not support by providing cover for him to deal more damage or that his support also helps extend the round's duration. Similarly, when Karthus is played with Nasus on the same side, he usually scores many fewer killing sprees compared to when he plays without Nasus. This is contrasting evidence that he is worse when playing synergisticly with Nasus.
Additionally, when Karthus plays with Nasus on the same side, he typically receives a little less damage than when he plays alone. Receiving not as much damage could indicate that Nasus does a decent job of protecting Karthus during teamfights.
There is no ideal champion pairing for Karthus that will 100% of the time be his top ally. Yet, Nasus is a very typical companion for Karthus. By playing on the same side as Karthus, he improves their win rate by 0.2% to 47.5%. This clearly indicates that there is only a small synergy between Karthus and Nasus that results in them performing stronger together than without each other.
Nasus has a lower difficulty than Karthus. That means you don't need to be very careful when finding Nasus teammates to play with, as they will require a relatively low level of skill to cooperate well with you.
Playing on the same side, you should witness an overall large increase in your team’s ability to deal magical damage. Combined, these champs are able to dish out a surprising amount of magic type damage.
Although, by aligning Karthus and Nasus together, you will not be providing your side very much utility. Make sure to include other champs on your team that helps cover this relative disparity in this pairing's capabilities.
Regardless of your Nasus ally's skill level, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you will do well, regardless.
To truly master Karthus in order to synergize with Nasus during both the laning and mid / late game phases of League of Legends, you should continue reading to gather some more tips and tricks for this champion pairing. If you mind the build and tips presented here, you will increase your win rate by a lot.
The ideal items to have in your Karthus and Nasus synergy build consist of Malignance, Stormsurge, and Liandry's Torment. When Karthus used at least these three items in his build, he performed much better when fighting alongside Nasus than with many other commonly used item sets. In fact, Karthus boasted an average win rate of 47.5% when playing alongside Nasus with these items in his kit.
To have the highest likelihood of coming out on top against your oponents, Karthus players should use the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune builds players picked for Karthus and Nasus pairings, this composite of runes yielded the best win rate. Moreover, these runes averaged a 47.5% winrate overall.
By default, tips, stats, and builds on how to pair Nasus with Karthus are displayed for all ranked divisions. To filter the statistics and builds to a specific rank, you may use the selection menu located earlier on the page.