Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Miss Fortune ramps up speed if she hasn't recently taken damage. Avoid getting hit to move very fast.
Use Double Up on the furthest enemy minion if enemy champions are hiding in back; it will bounce to them for lots of damage.
Make sure to utilize Love Tap while Strut is on cooldown to maximize the active's availability.
The Karthus Miss Fortune synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Miss Fortune, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Miss Fortune. His KDA went down from NaN to NaN. This fall shows that Miss Fortune helps Karthus perform worse in ranked LoL matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus is paired with Miss Fortune, he sees a small increase in his complete damage dealt. This change could signal that Miss Fortune provides protection for him to dish out more damage or that her presence also helps extend the match's duration. Similarly, when Karthus is played together with Miss Fortune on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Miss Fortune.
Moreover, when Karthus plays with Miss Fortune on the same side, he typically receives more damage than when he fights alone. Receiving more damage may mean that Miss Fortune does a poor job of protecting Karthus in team fights.
There is no top champion pairing for Karthus that will no matter what be his #1 synergy. Yet, Miss Fortune is a great companion for Karthus. By playing on the same side as Karthus, she increases their win rate by 3.3% to 50.6%. This signals that there is a very real synergy between Karthus and Miss Fortune that allows them to perform at the top of their game together than without each other.
Miss Fortune has a much lower diffuclty than Karthus. That means Karthus players don't need to be careful when finding Miss Fortune allies to go into battle on the same side as, as they will require a much lower level of skill to be able to do well with you.
When playing together, you should observe an overall large increase in your team’s capability to to do a lot of AP damage. Combined, these champions can deal quite a lot of AP type damage.
In contrast, by grouping Karthus and Miss Fortune together, you probably will not be giving your team a lot of protection for burst damage. Make sure to include other champions on your team that helps cover this relative gap in their potential.
Regardless of the skill of your Miss Fortune ally, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Karthus to pair well with Miss Fortune during both the laning and mid / late game phases of LoL matches, you should keep reading to learn a few extra tips and tricks for this champion pairing. If you pay attention to the build and tips shown above, you will increase your win rate significantly.
The best items to use in your Karthus and Miss Fortune synergy build include Rabadon's Deathcap, Malignance, and Luden's Companion. When Karthus used at least these three great items in his build, he did a lot better when fighting alongside Miss Fortune than with most other commonly used item sets. In fact, Karthus had an average win rate of 50.6% helping carry Miss Fortune with this build.
To have the greatest probability of annihilating your oponents, Karthus players should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players used for this team composition, this mixture of runes resulted in the highest win rate. Notably, these runes averaged a 50.6% win rate overall.
By default, tips, stats, and builds on how to team up Miss Fortune with Karthus are shown for all skill levels combined. If you want to filter the statistics and builds to a distinct player tier, you can use the selection menu located earlier on the page.