Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Lissandra's abilities are shorter range than those of many mages. As a result, buying items that offer both ability power and defense, like Zhonya's Hourglass and Banshee's Veil, can be a great choice to help her both survive and deal damage.
Casting Glacial Path and then running in the opposite direction will leave your enemies uncertain which way you will actually go.
You can instantly use your ultimate on yourself by pressing the self cast key and the ultimate key at once (alt+R by default).
The Karthus Lissandra synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Lissandra, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Lissandra. His KDA worsened from NaN to NaN. This fall shows that Lissandra helps Karthus perform not as well in competitive League games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus tries to synergize with Lissandra, he gets a marginal improvement in his complete damage output. This change may signal that Lissandra provides protection for him to dish out more damage or that her allyship also helps extend the match's duration. Similarly, when Karthus is played with Lissandra on the same team, he usually scores many fewer killing sprees than when he plays without Lissandra. This is contrasting evidence that he is worse when playing synergisticly with Lissandra.
Moreover, when Karthus plays with Lissandra on the same team, he often takes a little more damage than when he plays alone. Receiving more damage may indicate that Lissandra does a poor job of covering Karthus during teamfights.
There is no universally accepted best companion for Karthus that will always be his top synergy. However, Lissandra is a very bad teammate for Karthus. By being on the same team as Karthus, she drops their win rate by -4.7% to 42.6%. This proves that there is a terrible bond between Karthus and Lissandra that results in them performing worse together than without each other.
Lissandra has a lower difficulty than Karthus. That means Karthus players don't need to be careful when enlisting Lissandra allies to play with, as they will need a relatively low level of skill to be able to cooperate well with you.
When playing on the same side, Karthus players should expect to observe an overall large increase in your team’s capacity to deal magic damage. Together, these two can blast through enemies with magic damage.
In contrast, by pairing Karthus and Lissandra together, you may not be granting your side very much sustained damage output. Plan to pick other champs on your team that neutralizes this relative hole in their capabilities.
Regardless of the ability of your Lissandra teammate, you should focus on increasing your income, staying alive by avoiding foolish fights, and clearing objectives. If you do this, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus in order to work well with Lissandra during both the laning and mid / late game phases of LoL matches, you should continue reading to learn a few extra tips and tricks for this champion pairing. If you pay attention to the build and suggestions shown above, you should increase your win rate significantly.
The ideal finished items to have in your Karthus and Lissandra synergy build include Rabadon's Deathcap, Malignance, and Liandry's Torment. When Karthus incorporated at least these three items in his build, he did much better when paired up with Lissandra than with many other typical builds. In fact, Karthus had an average win rate of 42.6% when synergizing his build and playstyle to Lissandra with this build.
To have the highest probability of vanquishing your oponents, you should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Gathering Storm, and Transcendence runes from the Domination and Sorcery rune sets. Of all the rune sets players chose for Karthus and Lissandra pairings, this combination of runes resulted in the top win rate. Notably, these runes gave a 42.6% win rate overall.
By default, tips, stats, and builds on how to synergize Lissandra with Karthus are given for all skill levels combined. If you would like to narrow the stats and builds to a distinct division, you can use the selection menu earlier in the counter matchup guide.