Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Take advantage of Flurry by weaving in basic attacks between spell casts - this maximizes damage output and minimizes Energy loss.
Self-casting Safeguard and using Iron Will are powerful tools for killing neutral monsters (in the jungle).
Use Sonic Wave before Dragon's Rage so you can chase the target with Resonating Strike.
The Karthus Lee Sin synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Lee Sin, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Lee Sin. His KDA worsened from NaN to NaN. This worsening shows that Lee Sin helps Karthus perform worse in competitive League of Legends matches. Yet, the small difference shows that this performance change is only marginal.
When Karthus plays on the same team as Lee Sin, he gets a little increase in his total damage dealt. This change could demonstrate that Lee Sin supports by providing cover for him to deal more damage or that his participation also helps increase the match's duration. Similarly, when Karthus is played alongside Lee Sin on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Lee Sin.
Additionally, when Karthus plays with Lee Sin on the same team, he on average receives much less damage than when he fights alone. Taking not as much damage could indicate that Lee Sin does a decent job of protecting Karthus during team fights.
There is no ideal champion pairing for Karthus that will 100% of the time be his top teammate. However, overall, Lee Sin is a very bad ally for Karthus. By being on the same team as Karthus, he lowers their win rate by -3.3% to 44.0%. This demonstrates that there is a terrible bond between Karthus and Lee Sin that results in them performing worse together than alone.
Lee Sin has a lower difficulty than Karthus. That means Karthus players don't need to be careful when enlisting Lee Sin comrades to play with, as they will need a lower level of skill to be able to fight well with you.
Playing together, Karthus players should expect to see an overall large increase in your team’s ability to to do a lot of AP damage. When paired, these two can blast through enemies with magic damage.
Although, by pairing Karthus and Lee Sin together, you probably will not be providing your other allies very much cover. We recommend you include other champions on your team that nullifies this relative hole in their abilities.
Regardless of the skill of your Lee Sin teammate, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you do this, you will do well, regardless.
If you would like to learn all of the intricacies of Karthus in order to work well with Lee Sin during both the early game and mid / late game phases of League games, you should continue reading to pick up some more tips and tricks for this champion pairing. If you pay attention to the build and suggestions displayed here, you should grow your win rate significantly.
The most important items to include in your Karthus and Lee Sin synergy build consist of Rabadon's Deathcap, Malignance, and Shadowflame. When Karthus incorporated at least these three items in his build, he performed a lot better when fighting alongside Lee Sin than with most other typical builds. In fact, Karthus boasted an average win rate of 44.0% helping carry Lee Sin with these items in his kit.
To have the best likelihood of defeating your oponents, you should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune combinations we have analyed for this team composition, this blending of runes yielded the greatest win rate. Notably, these runes averaged a 44.0% winrate overall.
If you need to see Karthus with Lee Sin synergy tips and builds for a a specific division rank, feel free to select one from the selection menu displayed above. At first, the stats and tips and suggestions given are computed using every game finished with both champs.