Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Kayle benefits greatly from Attack Damage and Ability Power, making hybrid items like Nashor's Tooth and Hextech Gunblade very effective on her.
Using Divine Judgment on a high-DPS ally can turn the tides of battle by giving your ally free reign to attack.
Kayle's attacks become incredibly powerful once she gains attack range from Divine Ascent. Play safe until then.
The Karthus Kayle synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Kayle, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Kayle. His KDA fell from NaN to NaN. This negative change shows that Kayle helps Karthus perform poorer in ranked League of Legends rounds. Yet, the small difference indicates that this performance change is only marginal.
When Karthus plays on the same team as Kayle, he observes a barely noticable drop in his total damage dealt. This could indicate that Kayle does not help cover for him to deal more damage or that her presence also helps increase the match's duration. Similarly, when Karthus is played with Kayle on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Kayle.
Additionally, when Karthus plays with Kayle on the same side, he often takes a little more damage than when he fights alone. Taking more damage could mean that Kayle does a poor job of covering Karthus in team fights.
There is no perfect synergy for Karthus that will no matter what be his #1 synergy. However, overall, Kayle is a good companion for Karthus. By locking into the same team as Karthus, she improves their win rate by 1.5% to 48.8%. This demonstrates that there is a potentially meaningful synergy between Karthus and Kayle that allows them to perform at the top of their game together than alone.
Kayle has a lower difficulty than Karthus. That means you don't need to be very careful when lining up Kayle allies to fight alongside, as they will have to have a lower level of skill to be able to do well with you.
Fighting together, Karthus players should see an overall large increase in your team’s capability to deal magical damage. Together, these two can deal quite a lot of AP type damage.
Conversely, by grouping Karthus and Kayle together, you may not be giving your other allies much crowd control. Make sure to pick other champs on your team that neutralizes this relative hole in this pairing's kit.
Regardless of your Kayle ally's skill level, you should focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well anyway.
To truly master Karthus in order to synergize with Kayle during both the early game and mid / late game phases of League games, you should keep reading to master a few extra tricks and insights into this champion pairing. If you pay attention to the build and tips shown here, you will increase your win rate by a lot.
The most crucial items to use in your Karthus and Kayle synergy build include Rabadon's Deathcap, Shadowflame, and Liandry's Torment. When Karthus included at least these three pieces in his build, he performed much better as an ally of Kayle than with many other common builds. In fact, Karthus boasted an average win rate of 48.8% when synergizing his build and playstyle to Kayle with this build.
To have the best chance of crushing your oponents, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune combinations that we analyzed for this champion pairing, this blending of runes yielded the best win rate. Moreover, these runes gave a 48.8% win rate overall.
If you would like to view Karthus and Kayle cooperations tips and builds for a a particular division, please choose one from the selection menu shown above. By default, the stats and build suggestions shown are computed using all games run with both champs.