Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Karthus Kai'Sa synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Kai'Sa, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA went down from NaN to NaN. This drop shows that Kai'Sa helps Karthus perform not as well in competitive League matches. Yet, the small difference indicates that this performance change is not very impactful.
When Karthus is paired with Kai'Sa, he gets a barely noticable drop in his full damage dealt. This change could indicate that Kai'Sa does not help protection for him to dish out more damage or that her presence on the team also helps increase the match's duration. Similarly, when Karthus is played together with Kai'Sa on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing alongside Kai'Sa.
Moreover, when Karthus plays with Kai'Sa on the same team, he usually takes a little more damage than when he fights alone. Getting dealt more damage may mean that Kai'Sa does a poor job of protecting Karthus during teamfights.
There is no one best synergy for Karthus that will 100% of the time be his #1 teammate. Yet, overall, Kai'Sa is a terrible companion for Karthus. By being on the same team as Karthus, she lowers their win rate by -6.2% to 41.1%. This signals that there is an easy to overcome and exploit bond between Karthus and Kai'Sa that allows them to perform worse together than alone.
Kai'Sa has a lower difficulty than Karthus. That means Karthus players don't need to be careful when lining up Kai'Sa comrades to fight alongside, as they will require a lower level of skill to play well with you.
Working cooperatively, you will likely see an overall large increase in your team’s capability to to do a lot of AP damage. Together, these champions are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Karthus and Kai'Sa together, you will not be providing your other allies much utility. We recommend you pick other champs on your team that offsets this relative gap in this pairing's kit.
Regardless of the skill of your Kai'Sa ally, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus to work well with Kai'Sa during both the early game and mid / late game phases of League games, you should continue reading to master a few extra lessons on this champion pairing. If you listen to the build and stats displayed above, you will increase your win rate significantly.
The most crucial items to focus on in your Karthus and Kai'Sa synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus used at least these three great items in his build, he performed much better when paired up with Kai'Sa than with most other common builds. In fact, Karthus boasted an average winrate of 41.1% when synergizing his build and playstyle to Kai'Sa with these items in his kit.
To have the greatest chance of crushing your oponents, Karthus players should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune combinations players used for this team composition, this combo of runes resulted in the best win rate. Moreover, these runes averaged a 41.1% win rate overall.
By default, tips, statistics, and builds on how to team up Kai'Sa with Karthus are shown for all skill levels, merged. If you want to scope the stats and builds to an individual rank, you can use the selection menu earlier in the counter matchup guide.