Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
You can release Shield of Durand even while crowd controlled.
You can use the minimap ally icons to cast Hero's Entrance.
You can use the step back from Justice Punch to dodge enemy spells.
The Karthus Galio synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Galio, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Galio. His KDA fell from NaN to NaN. This drop shows that Galio helps Karthus perform poorer in competitive League of Legends rounds. Yet, the small difference shows that this performance change is only marginal.
When Karthus is an ally to Galio, he gets a small decrease in his complete damage output. This difference may signal that Galio does not provide cover for him to dish out more damage or that his allyship also helps increase the round's duration. Similarly, when Karthus is played together with Galio on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Galio.
Moreover, when Karthus plays with Galio on the same team, he typically takes a little more damage than when he plays alone. Taking more damage may indicate that Galio does a poor job of covering Karthus during team fights.
There is no universally accepted best ally for Karthus that will 100% of the time be his best teammate. However, overall, Galio is a not very good teammate for Karthus. By playing on the same side as Karthus, he decreases their win rate by -2.9% to 44.4%. This clearly indicates that there is a negative synergy between Karthus and Galio that allows them to perform not as well together than alone.
Galio has a lower difficulty than Karthus. That means you don't need to be cautious when enlisting Galio teammates to play with, as they will need a relatively low level of skill to be able to work well with you.
Working cooperatively, you should observe an overall large increase in your team’s capability to to do a lot of AP damage. Combined, these champs can deal quite a lot of AP type damage.
Conversely, by aligning Karthus and Galio together, you probably will not be granting your other allies a great deal of anti-tank damage dealing potential. Plan to bring other champions on your team that offsets this disparity in their potential.
Regardless of your Galio ally's skill level, you need to focus on increasing your income, staying alive by avoiding foolish fights, and clearing objectives. If you heed this simple advice, you will do well anyway.
If you would like to learn all of the intricacies of Karthus to pair well with Galio during both the early game and mid / late game phases of League of Legends, you should continue reading to learn a few extra lessons on this champion pairing. If you listen to the build and tips shown here, you should grow your win rate significantly.
The top finished items to get in your Karthus and Galio synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus used at least these three items in his build, he did a lot better when fighting alongside Galio than with most other typical builds. In fact, Karthus had an average winrate of 44.4% when synergizing his build and playstyle to Galio with this build.
To have the best chance of coming out on top against your oponents, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune builds players picked for Karthus and Galio pairings, this mix of runes yielded the greatest win rate. Moreover, these runes gave a 44.4% winrate overall.
If you want to view Karthus and Galio synergy tips and builds for a an individual player tier, please select one from the selection menu provided above. At first, the stats and guides shown are calculated using every match played with these champs.