Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Use Arcane Shift to help line up your other skill shots.
You can line up Trueshot Barrage to hit multiple minion waves or even Monsters.
You can play Ezreal either as a Attack Damage carry or Ability Power carry depending on how you build him.
The Karthus Ezreal synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Ezreal, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Ezreal. His KDA went down from NaN to NaN. This decrease shows that Ezreal helps Karthus perform worse in ranked LoL rounds. Yet, the small difference proves that this performance change is only marginal.
When Karthus is paired with Ezreal, he observes a marginal improvement in his total damage dealt. This change could demonstrate that Ezreal helps provide protection for him to deal more damage or that his support also helps extend the round's duration. Similarly, when Karthus is played together with Ezreal on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing alongside Ezreal.
Additionally, when Karthus plays with Ezreal on the same team, he usually receives more damage than when he plays alone. Receiving more damage could indicate that Ezreal does a poor job of covering Karthus during team fights.
There is no one best companion for Karthus that will always be his ideal synergy. Yet, overall, Ezreal is a very bad ally for Karthus. By locking into the same side as Karthus, he drops their win rate by -4.1% to 43.2%. This proves that there is a very bad strategic relationship between Karthus and Ezreal that allows them to perform not as well together than without each other.
Ezreal has a lower difficulty than Karthus. That means Karthus players don't need to be cautious when arranging Ezreal allies to go into battle on the same side as, as they will need a lower level of skill to play well with you.
Working together, you will likely observe an overall large increase in your team’s ability to deal magic damage. Together, these two can deal quite a lot of AP type damage.
Although, by grouping Karthus and Ezreal together, you probably will not be providing your team enough tankyness. We recommend you have other champions on your team that nullifies this relative disparity in this pairing's capabilities.
Regardless of your Ezreal ally's ability, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you do this, you will do well anyway.
If you would like to learn all of the intricacies of Karthus to pair well with Ezreal during both the lane and mid / late game phases of League of Legends matches, you should keep reading to learn some more tricks and insights into this champion pairing. If you listen to the build and tips shown above, you should grow your win rate by a lot.
The best items to use in your Karthus and Ezreal synergy build consist of Rabadon's Deathcap, Malignance, and Shadowflame. When Karthus included at least these three items in his build, he did much better when fighting alongside Ezreal than with many other commonly used builds. In fact, Karthus boasted an average win rate of 43.2% when synergizing his build and playstyle to Ezreal with this build.
To have the highest chance of defeating your oponents, Karthus players should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the runes we have analyed for this champion pairing, this combination of runes resulted in the top win rate. In fact, these runes averaged a 43.2% win rate overall.
By default, tips, statistics, and builds on how to synergize Ezreal with Karthus are shown for all skill levels, merged. If you would like to filter the stats and builds to a particular player tier, you may use the selection menu located at the top of this page.