Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Karthus Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This decrease shows that Cassiopeia helps Karthus perform worse in competitive League games. Yet, the small difference shows that this performance change is only marginal.
When Karthus tries to synergize with Cassiopeia, he observes a little increase in his total damage dealt. This difference could signal that Cassiopeia supports by providing cover for him to dish out more damage or that her allyship also helps extend the match's duration. Similarly, when Karthus is played with Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Cassiopeia.
Additionally, when Karthus plays with Cassiopeia on the same side, he often receives more damage than when he plays alone. Receiving more damage may indicate that Cassiopeia does a poor job of covering Karthus during team fights.
There is no universally accepted best ally for Karthus that will always be his top teammate. However, Cassiopeia is a very typical companion for Karthus. By playing on the same team as Karthus, she drops their win rate by -0.2% to 47.1%. This signals that there is only a small bond between Karthus and Cassiopeia that allows them to perform worse together than without each other.
Cassiopeia has a greater difficulty than Karthus. That means Karthus players should be cautious when enlisting Cassiopeia comrades to go into battle on the same side as, as they will need a greater level of skill to be able to work well with you.
Playing together, Karthus players should see an overall large increase in your team’s capacity to deal magical damage. Combined, these two are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Karthus and Cassiopeia together, you may not be granting your team very much sustained damage output. Plan to pick other champions on your team that fills this hole in their playstyle.
Regardless of your Cassiopeia ally's ability, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus in order to pair well with Cassiopeia during both the early game and mid / late game phases of LoL rounds, you should keep reading to master some more lessons on this champion pairing. If you listen to the build and tips shown above, you will increase your win rate by a lot.
The most crucial items to include in your Karthus and Cassiopeia synergy build include Malignance, Shadowflame, and Liandry's Torment. When Karthus combined at least these three great items in his build, he did significantly better as an ally of Cassiopeia than with many other typical item sets. In fact, Karthus had an average winrate of 47.1% when synergizing his build and playstyle to Cassiopeia with this build.
To have the best chance of defeating your oponents, you should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune sets we have analyed for this champion pairing, this combo of runes resulted in the best win rate. Moreover, these runes averaged a 47.1% win rate overall.
If you need to view Karthus with Cassiopeia synergy tips and builds for a a distinct division, feel free to select one from the selection menu shown above. If viewing for the first time, the stats and tips and suggestions displayed are calculated using all rounds run with these champions.