Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Akali excels at killing fragile champions. Let your team initiate and then strike at the people in the back.
Twilight Shroud offers safety in even the most dangerous situations. Use that time to save up energy for a quick strike later.
The Karthus Akali synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Akali, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Akali. His KDA decreased from NaN to NaN. This drop shows that Akali helps Karthus perform not as well in ranked LoL games. Yet, the small difference indicates that this performance change is only marginal.
When Karthus plays on the same team as Akali, he gets a little decrease in his complete damage dealt. This change may demonstrate that Akali does not help cover for him to dish out more damage or that her presence on the team also helps increase the round's duration. Similarly, when Karthus is played with Akali on the same side, he usually scores many fewer killing sprees compared to when he plays without Akali. This is contrasting evidence that he is worse when playing synergisticly with Akali.
Moreover, when Karthus plays with Akali on the same team, he usually receives a little more damage than when he plays alone. Getting dealt more damage may indicate that Akali does a poor job of covering Karthus in teamfights.
There is no ideal companion for Karthus that will always be his best ally. However, overall, Akali is a relatively poor companion for Karthus. By locking into the same side as Karthus, she decreases their win rate by -2.3% to 45.0%. This clearly indicates that there is a negative synergy between Karthus and Akali that allows them to perform not as well together than without each other.
Akali has a lower difficulty than Karthus. That means Karthus players don't need to be cautious when enlisting Akali allies to go into battle on the same side as, as they will need a lower level of skill to fight well with you.
When playing cooperatively, Karthus players will likely see an overall large increase in your team’s ability to deal magic damage. Combined, these champs can blast through enemies with magic damage.
Although, by grouping Karthus and Akali together, you will not be giving your other teammates a lot of engage potential. Plan to have other champions on your team that offsets this relative gap in this pairing's playstyle.
Regardless of the skill of your Akali ally, you need to focus on maximizing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you will do well anyway.
If you would like to truly master Karthus in order to synergize with Akali during both the lane and mid / late game phases of League games, you should keep reading to master additional tips and tricks for this champion pairing. If you pay attention to the build and stats displayed above, you will grow your win rate significantly.
The best finished items to get in your Karthus and Akali synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Karthus incorporated at least these three finished items in his build, he performed much better when fighting alongside Akali than with many other common item sets. In fact, Karthus boasted an average win rate of 45.0% when playing alongside Akali with this build.
To have the highest likelihood of coming out on top against your oponents, you should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune combinations players used for this team composition, this combo of runes yielded the top win rate. Moreover, these runes provided a 45.0% winrate overall.
By default, tips, statistics, and builds on how to synergize Akali with Karthus are shown for all skill levels, merged. If you want to narrow the stats and builds to a particular division, you may use the selection menu earlier in the counter matchup guide.