Don't be too conservative with Mantra. Gathering Fire is strongest in teamfights, making it easy to recharge Mantra multiple times.
Gathering Fire rewards aggressive play. Look to land abilities and basic attacks on your opponent to lower Mantra's cooldown and stay on the offensive.
When using Focused Resolve, slow your opponents with Inner Flame or speed yourself up with Inspire if you're having trouble sticking to a target.
Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Use Overload's passive to optimize for maximum damage or maximum speed.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
The Karma Ryze synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Ryze, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Karma sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Ryze. His KDA worsened from NaN to NaN. This negative change shows that Ryze helps Karma perform worse in ranked League games. Yet, the small difference proves that this performance change is not very impactful.
When Karma tries to synergize with Ryze, she observes a little decrease in her total damage output. This may demonstrate that Ryze doesn't help cover for her to deal more damage or that his presence also helps increase the round's duration. Similarly, when Karma is played alongside Ryze on the same side, he usually scores many fewer killing sprees compared to when she plays without Ryze. This is contrasting evidence that she is worse when playing synergisticly with Ryze.
Additionally, when Karma plays with Ryze on the same side, she usually takes a little more damage than when she fights alone. Getting dealt more damage could indicate that Ryze does a poor job of protecting Karma in teamfights.
There is no universally accepted best champion pairing for Karma that will no matter what be her ideal synergy. However, Ryze is a very typical companion for Karma. By playing on the same team as Karma, he drops their win rate by -1.0% to 47.3%. This proves that there is a weak bond between Karma and Ryze that results in them performing worse together than without each other.
Ryze has a greater difficulty than Karma. That means Karma players should be careful when enlisting Ryze teammates to fight alongside, as they will have to have a greater level of skill to fight well with you.
Fighting alongside, Karma players will likely see an overall large increase in your team’s capability to deal magical damage. Together, these two are able to dish out a surprising amount of magic type damage.
Conversely, by pairing Karma and Ryze together, you may not be providing your team much anti-tank damage dealing potential. Plan to bring other champs on your team that neutralizes this relative disparity in this pairing's abilities.
Regardless of the ability of your Ryze teammate, you need to focus on maximizing your income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well, regardless.
If you would like to truly master Karma to pair well with Ryze during both the lane and mid / late game phases of League rounds, you should continue reading to pick up a few extra tricks and insights into this champion pairing. If you listen to the build and tips presented above, you will increase your win rate significantly.
The most important finished items to use in your Karma and Ryze synergy build include Shurelya's Battlesong, Ardent Censer, and Zaz'Zak's Realmspike. When Karma used at least these three pieces in her build, she did much better when paired up with Ryze than with many other common builds. In fact, Karma boasted an average win rate of 47.3% when playing alongside Ryze with this build.
To have the highest probability of defeating your oponents, you should use the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Of all the rune builds players picked for this team composition, this mixture of runes yielded the highest win rate. In fact, these runes provided a 47.3% winrate overall.
By default, tips, stats, and builds on how to synergize Ryze with Karma are shown for all skill levels, merged. To scope the stats and builds to an individual rank, you should use the selection menu located earlier on the page.