Don't be too conservative with Mantra. Gathering Fire is strongest in teamfights, making it easy to recharge Mantra multiple times.
Gathering Fire rewards aggressive play. Look to land abilities and basic attacks on your opponent to lower Mantra's cooldown and stay on the offensive.
When using Focused Resolve, slow your opponents with Inner Flame or speed yourself up with Inspire if you're having trouble sticking to a target.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Karma Annie synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Annie, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Karma sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA worsened from NaN to NaN. This fall shows that Annie helps Karma perform worse in competitive LoL games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karma tries to synergize with Annie, she sees a little drop in her full damage output. This difference could signal that Annie does not provide protection for her to deal more damage or that her allyship also helps extend the match's duration. Similarly, when Karma is played alongside Annie on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing alongside Annie.
Moreover, when Karma plays with Annie on the same team, she typically takes a little less damage than when she fights alone. Getting dealt not as much damage may mean that Annie does a decent job of protecting Karma during teamfights.
There is no top champion pairing for Karma that will always be her #1 synergy. Yet, overall, Annie is a below average companion for Karma. By being on the same team as Karma, she lowers their win rate by -1.1% to 47.2%. This signals that there is a harmful bond between Karma and Annie that allows them to perform not as well together than alone.
Annie has a greater difficulty than Karma. That means you need to be cautious when arranging Annie allies to go into battle on the same side as, as they will need a greater level of skill to be able to cooperate well with you.
Fighting alongside, you should see an overall large increase in your team’s ability to to do a lot of AP damage. Together, these champions can blast through enemies with magic damage.
In contrast, by bringing Karma and Annie together, you will not be providing your other allies very much sustained damage output. Plan to include other champs on your team that fills this relative hole in this pairing's potential.
Regardless of the ability of your Annie teammate, you need to focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to learn all of the intricacies of Karma to synergize with Annie during both the lane and mid / late game phases of League, you should keep reading to pick up additional lessons on this champion pairing. If you use the build and stats displayed here, you should grow your win rate by a lot.
The most important finished items to build first in your Karma and Annie synergy build include Shurelya's Battlesong, Ardent Censer, and Zaz'Zak's Realmspike. When Karma combined at least these three great items in her build, she performed much better as an ally of Annie than with most other typical builds. In fact, Karma had an average winrate of 47.2% when playing alongside Annie with this build.
To have the greatest likelihood of defeating your oponents, you should equip the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Of all the rune sets players used for this champion pairing, this composite of runes resulted in the greatest win rate. In fact, these runes gave a 47.2% win rate overall.
By default, tips, stats, and builds on how to synergize Annie with Karma are shown for all ranked divisions combined. To scope the stats and builds to a particular division, you should use the selection menu located earlier on the page.