Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Kai'Sa Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA worsened from NaN to NaN. This drop shows that Vayne helps Kai'Sa perform poorer in ranked League games. Yet, the small difference shows that this performance change is not very impactful.
When Kai'Sa plays on the same team as Vayne, she observes a marginal improvement in her full damage dealt. This change may indicate that Vayne helps provide cover for her to dish out more damage or that her presence on the team also helps extend the match's duration. Similarly, when Kai'Sa is played with Vayne on the same side, he usually scores many fewer killing sprees compared to when she plays without Vayne. This is contrasting evidence that she is worse when playing with Vayne.
Additionally, when Kai'Sa plays with Vayne on the same team, she often receives a little less damage than when she fights alone. Getting dealt not as much damage may mean that Vayne does a decent job of covering Kai'Sa during team fights.
There is no universally accepted best champion pairing for Kai'Sa that will always be her #1 ally. Yet, Vayne is a very typical teammate for Kai'Sa. By playing on the same side as Kai'Sa, she has no effect on their win rate by 0.0% to 46.5%. This proves that there is not really a strong bond between Kai'Sa and Vayne that allows them to perform at the same level together than without each other.
Vayne has a greater difficulty than Kai'Sa. That means Kai'Sa players need to be cautious when enlisting Vayne teammates to play with, as they will require a greater level of skill to be able to play well with you.
When playing alongside, you should expect to see an overall large increase in your team’s capability to dish out massive AD. When paired, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by pairing Kai'Sa and Vayne together, you probably will not be giving your side much magic damage. Make sure to bring other champions on your team that offsets this gap in their kit.
Regardless of the skill of your Vayne ally, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to truly master Kai'Sa to synergize with Vayne during both the early game and mid / late game phases of League of Legends matches, you should keep reading to learn some more tricks and insights into this champion pairing. If you pay attention to the build and suggestions shown here, you will grow your win rate significantly.
The most crucial finished items to include in your Kai'Sa and Vayne synergy build include Muramana, Stormsurge, and Luden's Companion. When Kai'Sa used at least these three finished items in her build, she did a lot better as an ally of Vayne than with most other common builds. In fact, Kai'Sa had an average win rate of 46.5% helping carry Vayne with this build.
To have the highest probability of coming out on top against your oponents, Kai'Sa players should take the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Biscuit Delivery, and Magical Footwear runes from the Domination and Inspiration rune sets. Of all the runes players picked for this champion pairing, this combination of runes resulted in the greatest win rate. Notably, these runes averaged a 46.5% winrate overall.
If you want to view Kai'Sa with Vayne synergy tips and stats for a an individual rank, feel free to choose one from the selection menu shown above. By default, the stats and guides displayed are computed using all games with data with these champions.