Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The Kai'Sa Twitch synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Twitch, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Twitch. His KDA fell from NaN to NaN. This worsening shows that Twitch helps Kai'Sa perform not as well in ranked League of Legends games. Yet, the small difference proves that this performance change is only marginal.
When Kai'Sa is paired with Twitch, she gets a little decrease in her full damage dealt. This may indicate that Twitch doesn't help protection for her to deal more damage or that his presence also helps increase the game's duration. Similarly, when Kai'Sa is played with Twitch on the same side, he usually scores many fewer killing sprees compared to when she plays without Twitch. This is contrasting evidence that she is worse when playing with Twitch.
Additionally, when Kai'Sa plays with Twitch on the same side, she typically receives a little more damage than when she plays alone. Taking more damage may mean that Twitch does a poor job of covering Kai'Sa in team fights.
There is no ideal ally for Kai'Sa that will always be her ideal synergy. Yet, overall, Twitch is a below average ally for Kai'Sa. By being on the same team as Kai'Sa, he drops their win rate by -1.6% to 44.9%. This signals that there is a harmful bond between Kai'Sa and Twitch that allows them to perform not as well together than without each other.
Twitch has a lower difficulty than Kai'Sa. That means you don't need to be very careful when finding Twitch allies to play with, as they will require a relatively low level of skill to do well with you.
Playing alongside, you will likely see an overall large increase in your team’s capacity to dish out massive AD. Combined, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by grouping Kai'Sa and Twitch together, you will not be giving your other allies very much utility. Make sure to pick other champions on your team that neutralizes this disparity in this pairing's capabilities.
Regardless of the skill of your Twitch ally, you should focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you should do well, regardless.
To truly master Kai'Sa to pair well with Twitch during both the lane and mid / late game phases of League of Legends, you should continue reading to master additional lessons on this champion pairing. If you listen to the build and suggestions shown here, you will increase your win rate by a lot.
The most important items to have in your Kai'Sa and Twitch synergy build consist of Guinsoo's Rageblade, Blade of The Ruined King, and Terminus. When Kai'Sa combined at least these three finished items in her build, she performed significantly better when fighting alongside Twitch than with most other common item sets. In fact, Kai'Sa boasted an average winrate of 44.9% when playing alongside Twitch with these items in her kit.
To have the best probability of crushing your oponents, Kai'Sa players should take the Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace, Biscuit Delivery, and Magical Footwear runes from the Precision and Inspiration rune sets. Out of all the rune sets players chose for Kai'Sa and Twitch pairings, this order of runes resulted in the highest win rate. Moreover, these runes gave a 44.9% win rate overall.
If you want to get Kai'Sa with Twitch synergy tips and builds for a a specific player tier, please select one from the selection menu displayed above. By default, the statistics and guides given are computed using every match with data with these champs.