Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Kai'Sa Senna synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Senna, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Senna. His KDA worsened from NaN to NaN. This worsening shows that Senna helps Kai'Sa perform worse in competitive LoL matches. Yet, the small difference shows that this performance change is not very impactful.
When Kai'Sa plays on the same team as Senna, she gets a noticable drop in her complete damage output. This difference could indicate that Senna doesn't help cover for her to deal more damage or that her support also helps increase the round's duration. Similarly, when Kai'Sa is played with Senna on the same team, he usually scores many fewer killing sprees compared to when she plays without Senna. This is contrasting evidence that she is worse when playing synergisticly with Senna.
Moreover, when Kai'Sa plays with Senna on the same side, she often takes a little more damage than when she plays alone. Taking more damage may mean that Senna does a poor job of protecting Kai'Sa in teamfights.
There is no universally accepted best champion pairing for Kai'Sa that will always be her top synergy. Yet, Senna is a relatively poor teammate for Kai'Sa. By playing on the same team as Kai'Sa, she lowers their win rate by -1.6% to 44.9%. This clearly indicates that there is a harmful bond between Kai'Sa and Senna that results in them performing not as well together than alone.
Senna has a greater difficulty than Kai'Sa. That means Kai'Sa players must be cautious when enlisting Senna allies to fight alongside, as they will need a greater level of skill to cooperate well with you.
When playing together, you should expect to observe an overall large increase in your team’s capability to dish out massive AD. Together, these two should be able to take down targets with auto-attacks and other AD damage abilities.
In contrast, by bringing Kai'Sa and Senna together, you may not be granting your side very much protection for burst damage. Make sure to have other champs on your team that fills this relative gap in their playstyle.
Regardless of your Senna ally's ability, you need to focus on increasing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you heed this simple advice, you should do well anyway.
If you would like to truly master Kai'Sa to work well with Senna during both the early game and mid / late game phases of League of Legends matches, you should keep reading to learn some more tricks and insights into this champion pairing. If you mind the build and suggestions displayed above, you should grow your win rate by a lot.
The most important finished items to have in your Kai'Sa and Senna synergy build include Guardian Angel, Guinsoo's Rageblade, and Kraken Slayer. When Kai'Sa included at least these three great items in her build, she performed significantly better as an ally of Senna than with many other commonly used builds. In fact, Kai'Sa boasted an average win rate of 44.9% when synergizing her build and playstyle to Senna with these items in her kit.
To have the best chance of beating your oponents, Kai'Sa players should use the Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the rune builds players picked for this team composition, this composite of runes resulted in the highest win rate. In fact, these runes averaged a 44.9% win rate overall.
By default, tips, stats, and builds on how to synergize Senna with Kai'Sa are displayed for all ranked divisions combined. If you want to scope the stats and builds to a distinct skill level, you should use the selection menu above.