Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Kai'Sa Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA fell from NaN to NaN. This fall shows that Karthus helps Kai'Sa perform worse in ranked League rounds. Yet, the small difference shows that this performance change is not very impactful.
When Kai'Sa is an ally to Karthus, she observes a marginal improvement in her total damage output. This may signal that Karthus provides cover for her to deal more damage or that his presence on the team also helps increase the round's duration. Similarly, when Kai'Sa is played with Karthus on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing with Karthus.
Moreover, when Kai'Sa plays with Karthus on the same team, she usually receives more damage than when she fights alone. Getting dealt more damage may indicate that Karthus does a poor job of protecting Kai'Sa in team fights.
There is no one best companion for Kai'Sa that will 100% of the time be her best ally. However, Karthus is a very bad companion for Kai'Sa. By being on the same team as Kai'Sa, he decreases their win rate by -5.4% to 41.1%. This shows that there is a terrible synergy between Kai'Sa and Karthus that results in them performing worse together than alone.
Karthus has a greater difficulty than Kai'Sa. That means you must be careful when enlisting Karthus allies to go into battle on the same side as, as they will need a greater level of skill to be able to work well with you.
Fighting alongside, you should witness an overall large increase in your team’s capacity to deal magical damage. Combined, these champions are able to dish out a surprising amount of magic type damage.
Although, by aligning Kai'Sa and Karthus together, you will not be granting your team very much crowd control. Make sure to bring other champs on your team that neutralizes this hole in their potential.
Regardless of your Karthus ally's skill level, you should focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you will do well anyway.
To truly master Kai'Sa to pair well with Karthus during both the early game and mid / late game phases of LoL rounds, you should continue reading to pick up additional tricks and insights into this champion pairing. If you listen to the build and stats shown above, you should grow your win rate by a lot.
The most crucial finished items to use in your Kai'Sa and Karthus synergy build consist of Wit's End, Guinsoo's Rageblade, and Kraken Slayer. When Kai'Sa used at least these three great items in her build, she did much better when paired up with Karthus than with many other commonly used item sets. In fact, Kai'Sa had an average win rate of 41.1% when playing alongside Karthus with this build.
To have the highest likelihood of defeating your oponents, Kai'Sa players should take the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Biscuit Delivery, and Magical Footwear runes from the Domination and Inspiration rune sets. Out of all the rune combinations we have analyed for Kai'Sa and Karthus pairings, this sequence of runes resulted in the top win rate. Moreover, these runes provided a 41.1% winrate overall.
By default, tips, statistics, and builds on how to synergize Karthus with Kai'Sa are presented for all ranked divisions. To filter the stats and builds to a specific division, you may use the selection menu located earlier in the counter matchup guide.