Gwen can still damage enemies outside her Hallowed Mists, especially with her Ultimate's range.
Some of Gwen's Abilities can apply her passive to multiple enemies, so aim them at groups to get maximum damage and healing.
Always be Attacking - In addition to dealing bonus damage, Gwen's Attacks empower or reset many of her Abilities.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Gwen Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Gwen sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This negative change shows that Karthus helps Gwen perform worse in ranked League matches. Yet, the small difference shows that this performance change is only marginal.
When Gwen is an ally to Karthus, she gets a small increase in her complete damage output. This change could signal that Karthus supports by providing protection for her to dish out more damage or that his presence also helps extend the round's duration. Similarly, when Gwen is played together with Karthus on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Karthus.
Additionally, when Gwen plays with Karthus on the same team, she typically receives more damage than when she fights alone. Getting dealt more damage may mean that Karthus does a poor job of protecting Gwen in teamfights.
There is no perfect ally for Gwen that will no matter what be her top synergy. However, Karthus is a very bad companion for Gwen. By being on the same side as Gwen, he drops their win rate by -3.9% to 44.2%. This signals that there is a terrible bond between Gwen and Karthus that results in them performing worse together than alone.
Karthus has a greater difficulty than Gwen. That means you need to be very careful when enlisting Karthus teammates to fight alongside, as they will need a greater level of skill to fight well with you.
Working cooperatively, you will likely witness an overall large increase in your team’s ability to deal magical damage. Combined, these champs are able to dish out a surprising amount of magic type damage.
In contrast, by bringing Gwen and Karthus together, you will not be granting your other allies a lot of tankyness. Plan to have other champions on your team that fills this relative disparity in their potential.
Regardless of your Karthus ally's skill level, you need to focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you will do well anyway.
If you would like to learn all of the intricacies of Gwen in order to work well with Karthus during both the lane and mid / late game phases of League of Legends rounds, you should keep reading to learn a few extra lessons on this champion pairing. If you listen to the build and suggestions presented here, you will increase your win rate by a lot.
The best finished items to use in your Gwen and Karthus synergy build include Nashor's Tooth, Zhonya's Hourglass, and Riftmaker. When Gwen included at least these three items in her build, she performed much better when fighting alongside Karthus than with most other typical item sets. In fact, Gwen boasted an average winrate of 44.2% helping carry Karthus with these items in her kit.
To have the greatest chance of annihilating your oponents, Gwen players should take the Conqueror, Presence of Mind, Legend: Alacrity, Last Stand, Bone Plating, and Unflinching runes from the Precision and Resolve rune sets. Of all the runes players chose for this champion pairing, this sequence of runes yielded the top win rate. Moreover, these runes gave a 44.2% win rate overall.
If you want to get Gwen with Karthus cooperations tips and stats for a a particular skill level, please choose one from the selection menu above. If viewing for the first time, the statistics and strategies shown are calculated using every match with data with both champs.