Use Arcane Shift to help line up your other skill shots.
You can line up Trueshot Barrage to hit multiple minion waves or even Monsters.
You can play Ezreal either as a Attack Damage carry or Ability Power carry depending on how you build him.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Ezreal Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Ezreal sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This decrease shows that Karthus helps Ezreal perform poorer in competitive League of Legends rounds. Yet, the small difference shows that this performance change is not very impactful.
When Ezreal plays on the same team as Karthus, he sees a little increase in his complete damage output. This may demonstrate that Karthus helps provide protection for him to dish out more damage or that his allyship also helps extend the match's duration. Similarly, when Ezreal is played alongside Karthus on the same side, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Karthus.
Additionally, when Ezreal plays with Karthus on the same side, he on average takes more damage than when he plays alone. Receiving more damage could indicate that Karthus does a poor job of protecting Ezreal in teamfights.
There is no one best ally for Ezreal that will no matter what be his best ally. Yet, overall, Karthus is a very bad ally for Ezreal. By playing on the same team as Ezreal, he decreases their win rate by -3.7% to 43.2%. This demonstrates that there is a terrible strategic relationship between Ezreal and Karthus that allows them to perform worse together than without each other.
Karthus has a lower difficulty than Ezreal. That means Ezreal players don't need to be cautious when finding Karthus allies to go into battle on the same side as, as they will need a relatively low level of skill to fight well with you.
Working alongside, Ezreal players will likely witness an overall large increase in your team’s ability to deal magical damage. Together, these champs are able to dish out a surprising amount of magic type damage.
In contrast, by aligning Ezreal and Karthus together, you probably will not be giving your team much cover. We recommend you bring other champions on your team that helps cover this relative gap in their potential.
Regardless of your Karthus ally's skill level, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you heed this simple advice, you should do well, regardless.
To learn all of the intricacies of Ezreal in order to pair well with Karthus during both the lane and mid / late game phases of League matches, you should keep reading to learn additional tips and tricks for this champion pairing. If you use the build and stats displayed above, you should grow your win rate significantly.
The most important finished items to get in your Ezreal and Karthus synergy build consist of Muramana, Spear of Shojin, and Serylda's Grudge. When Ezreal bought at least these three finished items in his build, he performed much better when paired up with Karthus than with most other common builds. In fact, Ezreal boasted an average win rate of 43.2% helping carry Karthus with these items in his kit.
To have the best probability of crushing your oponents, you should use the Press the Attack, Presence of Mind, Legend: Bloodline, Coup de Grace, Magical Footwear, and Biscuit Delivery runes from the Precision and Inspiration rune sets. Out of all the rune builds players used for Ezreal and Karthus pairings, this order of runes resulted in the top win rate. Moreover, these runes averaged a 43.2% winrate overall.
By default, tips, stats, and builds on how to team up Karthus with Ezreal are given for all ranked divisions. To narrow the statistics and builds to an individual rank, you should use the selection menu located above.