Using Rupture on creeps in combination with Carnivore is a good way to gain Health and Mana.
If you're having difficulty feasting upon champions, try eating minions until you're larger.
Try to line up your attacks with Vorpal Spikes so that they kill minions and harass enemy champions at the same time.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Cho'Gath Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Cho'Gath sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA went down from NaN to NaN. This negative change shows that Karthus helps Cho'Gath perform worse in competitive League rounds. Yet, the small difference proves that this performance change is only marginal.
When Cho'Gath is paired with Karthus, he observes a small increase in his complete damage dealt. This change could signal that Karthus helps provide protection for him to dish out more damage or that his presence on the team also helps increase the round's duration. Similarly, when Cho'Gath is played with Karthus on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing with Karthus.
Additionally, when Cho'Gath plays with Karthus on the same side, he on average takes more damage than when he fights alone. Receiving more damage may indicate that Karthus does a poor job of covering Cho'Gath in teamfights.
There is no top synergy for Cho'Gath that will always be his #1 teammate. However, Karthus is a terrible companion for Cho'Gath. By playing on the same team as Cho'Gath, he drops their win rate by -4.3% to 45.2%. This demonstrates that there is an easy to overcome and exploit strategic relationship between Cho'Gath and Karthus that allows them to perform worse together than alone.
Karthus has a greater difficulty than Cho'Gath. That means you need to be careful when lining up Karthus allies to fight alongside, as they will need a greater level of skill to be able to work well with you.
Working together, Cho'Gath players will likely witness an overall large increase in your team’s ability to deal magic damage. Combined, these champions are able to dish out a surprising amount of magic type damage.
In contrast, by pairing Cho'Gath and Karthus together, you probably will not be granting your other allies very much anti-tank damage dealing potential. Make sure to have other champs on your team that neutralizes this relative hole in their playstyle.
Regardless of the ability of your Karthus ally, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you should do well anyway.
If you would like to truly master Cho'Gath to work well with Karthus during both the early game and mid / late game phases of League matches, you should continue reading to learn additional lessons on this champion pairing. If you pay attention to the build and stats shown here, you will increase your win rate by a lot.
The best finished items to focus on in your Cho'Gath and Karthus synergy build include Kaenic Rookern, Sunfire Aegis, and Heartsteel. When Cho'Gath combined at least these three pieces in his build, he did significantly better when paired up with Karthus than with many other typical item sets. In fact, Cho'Gath boasted an average winrate of 45.2% when playing alongside Karthus with this build.
To have the best likelihood of beating your oponents, you should equip the Grasp of the Undying, Demolish, Conditioning, Overgrowth, Legend: Tenacity, and Triumph runes from the Resolve and Precision rune sets. Of all the rune builds players picked for Cho'Gath and Karthus pairings, this blending of runes yielded the greatest win rate. Moreover, these runes averaged a 45.2% winrate overall.
If you would like to view Cho'Gath and Karthus collaboration tips and builds for a a particular division rank, please choose one from the selection menu provided above. At first, the stats and guides given are computed using all games played with these champs.