Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
The Cassiopeia Vladimir synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vladimir, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Vladimir. His KDA fell from NaN to NaN. This decrease shows that Vladimir helps Cassiopeia perform worse in ranked League rounds. Yet, the small difference shows that this performance change is only marginal.
When Cassiopeia is an ally to Vladimir, she sees a barely noticable drop in her full damage output. This may demonstrate that Vladimir does not provide cover for her to dish out more damage or that his presence also helps extend the match's duration. Similarly, when Cassiopeia is played alongside Vladimir on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing with Vladimir.
Additionally, when Cassiopeia plays with Vladimir on the same team, she usually receives a little less damage than when she plays alone. Getting dealt not as much damage may indicate that Vladimir does a decent job of covering Cassiopeia during team fights.
There is no universally accepted best synergy for Cassiopeia that will always be her best ally. However, Vladimir is a good teammate for Cassiopeia. By locking into the same team as Cassiopeia, he improves their win rate by 1.6% to 51.9%. This shows that there is a potentially meaningful synergy between Cassiopeia and Vladimir that allows them to perform stronger together than without each other.
Vladimir has a much lower diffuclty than Cassiopeia. That means you don't need to be cautious when enlisting Vladimir comrades to fight alongside, as they will require a much lower level of skill to do well with you.
Fighting cooperatively, Cassiopeia players will likely see an overall large increase in your team’s ability to to do a lot of AP damage. Combined, these champs can blast through enemies with magic damage.
Although, by aligning Cassiopeia and Vladimir together, you probably will not be providing your team very much sustained damage output. We recommend you bring other champions on your team that nullifies this disparity in their playstyle.
Regardless of your Vladimir ally's ability, you need to focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well, regardless.
To learn all of the intricacies of Cassiopeia in order to work well with Vladimir during both the laning and mid / late game phases of League of Legends rounds, you should continue reading to gather additional tricks and insights into this champion pairing. If you pay attention to the build and tips shown above, you should increase your win rate by a lot.
The most important items to get in your Cassiopeia and Vladimir synergy build include Seraph's Embrace, Rylai's Crystal Scepter, and Rod of Ages. When Cassiopeia included at least these three finished items in her build, she did much better when paired up with Vladimir than with most other common builds. In fact, Cassiopeia had an average winrate of 51.9% when synergizing her build and playstyle to Vladimir with this build.
To have the highest probability of crushing your oponents, Cassiopeia players should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune combinations players used for this champion pairing, this composite of runes resulted in the highest win rate. Notably, these runes provided a 51.9% win rate overall.
By default, tips, stats, and builds on how to synergize Vladimir with Cassiopeia are displayed for all skill levels, merged. To narrow the stats and builds to a distinct rank, you may use the selection menu located earlier in the counter matchup guide.