Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Cassiopeia Qiyana synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Qiyana, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Qiyana. His KDA worsened from NaN to NaN. This fall shows that Qiyana helps Cassiopeia perform worse in ranked LoL rounds. Yet, the small difference proves that this performance change is only marginal.
When Cassiopeia plays on the same team as Qiyana, she observes a little drop in her full damage output. This difference may signal that Qiyana does not support by providing protection for her to dish out more damage or that her presence also helps extend the game's duration. Similarly, when Cassiopeia is played together with Qiyana on the same side, he usually scores many fewer killing sprees compared to when she plays without Qiyana. This is contrasting evidence that she is worse when playing synergisticly with Qiyana.
Additionally, when Cassiopeia plays with Qiyana on the same team, she usually takes a little less damage than when she plays alone. Taking not as much damage may indicate that Qiyana does a decent job of covering Cassiopeia in teamfights.
There is no ideal synergy for Cassiopeia that will always be her best ally. However, Qiyana is a very bad companion for Cassiopeia. By playing on the same side as Cassiopeia, she drops their win rate by -4.7% to 45.6%. This shows that there is an easy to overcome and exploit synergy between Cassiopeia and Qiyana that results in them performing not as well together than alone.
Qiyana has a lower difficulty than Cassiopeia. That means Cassiopeia players don't need to be very careful when lining up Qiyana comrades to go into battle on the same side as, as they will require a relatively low level of skill to do well with you.
Playing on the same side, you will likely observe an overall large increase in your team’s capacity to to do a lot of AP damage. When paired, these two can blast through enemies with magic damage.
Although, by grouping Cassiopeia and Qiyana together, you will not be providing your other allies enough sustained damage output. Make sure to include other champs on your team that helps cover this gap in their abilities.
Regardless of your Qiyana ally's ability, you need to focus on maximizing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well anyway.
To learn all of the intricacies of Cassiopeia in order to work well with Qiyana during both the lane and mid / late game phases of League of Legends matches, you should keep reading to master a few extra tricks and insights into this champion pairing. If you listen to the build and stats displayed above, you will grow your win rate significantly.
The most important finished items to prioritize in your Cassiopeia and Qiyana synergy build consist of Seraph's Embrace, Rylai's Crystal Scepter, and Rod of Ages. When Cassiopeia combined at least these three finished items in her build, she performed significantly better when paired up with Qiyana than with most other typical item sets. In fact, Cassiopeia boasted an average winrate of 45.6% when synergizing her build and playstyle to Qiyana with these items in her kit.
To have the highest chance of vanquishing your oponents, Cassiopeia players should take the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune combinations players chose for this champion pairing, this combination of runes resulted in the best win rate. Notably, these runes averaged a 45.6% win rate overall.
If you need to see Cassiopeia and Qiyana synergy tips and stats for a a specific division rank, feel free to choose one from the selection menu above. At first, the stats and strategies given are calculated using every round played with these champs.