Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
The Cassiopeia Neeko synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Neeko, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Neeko. His KDA decreased from NaN to NaN. This decrease shows that Neeko helps Cassiopeia perform poorer in competitive League of Legends matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Cassiopeia plays on the same team as Neeko, she sees a barely noticable drop in her full damage dealt. This could indicate that Neeko does not help protection for her to deal more damage or that her presence also helps increase the round's duration. Similarly, when Cassiopeia is played alongside Neeko on the same team, he usually scores many fewer killing sprees than when she plays without Neeko. This is contrasting evidence that she is worse when playing with Neeko.
Additionally, when Cassiopeia plays with Neeko on the same side, she often receives a little more damage than when she plays alone. Receiving more damage could indicate that Neeko does a poor job of covering Cassiopeia in team fights.
There is no ideal champion pairing for Cassiopeia that will no matter what be her ideal synergy. However, overall, Neeko is a relatively poor companion for Cassiopeia. By playing on the same team as Cassiopeia, she drops their win rate by -1.4% to 48.9%. This clearly indicates that there is a harmful synergy between Cassiopeia and Neeko that allows them to perform not as well together than alone.
Neeko has a much lower diffuclty than Cassiopeia. That means you don't need to be careful when finding Neeko comrades to fight alongside, as they will have to have a much lower level of skill to fight well with you.
Fighting on the same side, Cassiopeia players will likely observe an overall large increase in your team’s capability to deal magic damage. When paired, these champions are able to dish out a surprising amount of magic type damage.
Conversely, by pairing Cassiopeia and Neeko together, you will not be granting your other teammates enough attack damage. Plan to have other champs on your team that fills this gap in their potential.
Regardless of your Neeko ally's skill level, you need to focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you should do well anyway.
To truly master Cassiopeia in order to synergize with Neeko during both the laning and mid / late game phases of League of Legends games, you should continue reading to gather some more tricks and insights into this champion pairing. If you pay attention to the build and tips displayed here, you will increase your win rate significantly.
The most crucial items to build first in your Cassiopeia and Neeko synergy build include Seraph's Embrace, Liandry's Torment, and Rod of Ages. When Cassiopeia combined at least these three finished items in her build, she did a lot better when paired up with Neeko than with most other common item sets. In fact, Cassiopeia had an average winrate of 48.9% when playing alongside Neeko with these items in her kit.
To have the best chance of annihilating your oponents, you should use the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune combinations players picked for this champion pairing, this combination of runes yielded the best win rate. Moreover, these runes provided a 48.9% win rate overall.
By default, tips, statistics, and builds on how to team up Neeko with Cassiopeia are presented for all skill levels combined. To filter the statistics and builds to an individual skill level, you can use the selection menu above.