Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
The Cassiopeia Kassadin synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kassadin, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kassadin. His KDA decreased from NaN to NaN. This decrease shows that Kassadin helps Cassiopeia perform worse in ranked League of Legends games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Cassiopeia is paired with Kassadin, she gets a little increase in her full damage output. This difference may indicate that Kassadin helps provide cover for her to dish out more damage or that his presence on the team also helps extend the game's duration. Similarly, when Cassiopeia is played with Kassadin on the same side, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Kassadin.
Additionally, when Cassiopeia plays with Kassadin on the same team, she typically receives more damage than when she plays alone. Getting dealt more damage may mean that Kassadin does a poor job of protecting Cassiopeia in teamfights.
There is no one best synergy for Cassiopeia that will always be her top teammate. Yet, overall, Kassadin is a very bad companion for Cassiopeia. By being on the same side as Cassiopeia, he drops their win rate by -4.9% to 45.4%. This demonstrates that there is a very bad bond between Cassiopeia and Kassadin that results in them performing worse together than without each other.
Kassadin has a lower difficulty than Cassiopeia. That means Cassiopeia players don't need to be cautious when lining up Kassadin comrades to play with, as they will need a lower level of skill to do well with you.
Playing alongside, Cassiopeia players should see an overall large increase in your team’s capability to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
In contrast, by aligning Cassiopeia and Kassadin together, you may not be granting your side a great deal of AD. Make sure to include other champs on your team that offsets this hole in their abilities.
Regardless of your Kassadin ally's ability, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well, regardless.
To truly master Cassiopeia in order to pair well with Kassadin during both the early game and mid / late game phases of League rounds, you should keep reading to master some more tips and tricks for this champion pairing. If you listen to the build and tips presented here, you will grow your win rate significantly.
The best finished items to focus on in your Cassiopeia and Kassadin synergy build include Seraph's Embrace, Rylai's Crystal Scepter, and Rod of Ages. When Cassiopeia included at least these three items in her build, she performed much better when paired up with Kassadin than with many other commonly used builds. In fact, Cassiopeia boasted an average winrate of 45.4% when synergizing her build and playstyle to Kassadin with these items in her kit.
To have the highest likelihood of crushing your oponents, Cassiopeia players should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune sets that we analyzed for this champion pairing, this combo of runes yielded the top win rate. Notably, these runes provided a 45.4% win rate overall.
By default, tips, stats, and builds on how to pair Kassadin with Cassiopeia are shown for every ranked division. To scope the statistics and builds to a particular division, you can use the selection menu located above.