Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Cassiopeia Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This worsening shows that Karthus helps Cassiopeia perform worse in competitive League of Legends games. Yet, the small difference indicates that this performance change is only marginal.
When Cassiopeia tries to synergize with Karthus, she gets a little drop in her total damage output. This difference could signal that Karthus doesn't help cover for her to deal more damage or that his participation also helps increase the match's duration. Similarly, when Cassiopeia is played with Karthus on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Karthus.
Moreover, when Cassiopeia plays with Karthus on the same side, she typically takes more damage than when she plays alone. Taking more damage may mean that Karthus does a poor job of protecting Cassiopeia in team fights.
There is no one best companion for Cassiopeia that will 100% of the time be her ideal synergy. Yet, Karthus is a very bad teammate for Cassiopeia. By locking into the same team as Cassiopeia, he decreases their win rate by -3.2% to 47.1%. This shows that there is an easy to overcome and exploit bond between Cassiopeia and Karthus that allows them to perform worse together than without each other.
Karthus has a much lower diffuclty than Cassiopeia. That means Cassiopeia players don't need to be careful when arranging Karthus allies to go into battle on the same side as, as they will have to have a much lower level of skill to be able to cooperate well with you.
Fighting on the same side, you should expect to observe an overall large increase in your team’s capability to deal magic damage. Together, these champs are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Cassiopeia and Karthus together, you probably will not be providing your other teammates a lot of AD. Plan to include other champs on your team that nullifies this relative hole in this pairing's abilities.
Regardless of your Karthus ally's skill level, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well anyway.
To truly master Cassiopeia to work well with Karthus during both the laning and mid / late game phases of League rounds, you should continue reading to gather some more lessons on this champion pairing. If you mind the build and tips displayed above, you will grow your win rate by a lot.
The top finished items to build first in your Cassiopeia and Karthus synergy build include Seraph's Embrace, Liandry's Torment, and Rod of Ages. When Cassiopeia incorporated at least these three items in her build, she did much better when paired up with Karthus than with most other common item sets. In fact, Cassiopeia had an average winrate of 47.1% when playing alongside Karthus with these items in her kit.
To have the highest probability of crushing your oponents, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the rune builds players chose for this team composition, this sequence of runes resulted in the top win rate. Notably, these runes averaged a 47.1% win rate overall.
By default, tips, statistics, and builds on how to synergize Karthus with Cassiopeia are presented for all skill levels combined. To filter the statistics and builds to a distinct division, you should use the selection menu located earlier in the counter matchup guide.