Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Cassiopeia Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA decreased from NaN to NaN. This decrease shows that Kai'Sa helps Cassiopeia perform not as well in competitive League of Legends games. Yet, the small difference proves that this performance change is only marginal.
When Cassiopeia tries to synergize with Kai'Sa, she observes a small decrease in her total damage output. This difference may demonstrate that Kai'Sa does not support by providing protection for her to deal more damage or that her support also helps extend the match's duration. Similarly, when Cassiopeia is played together with Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when she plays on his own. This is contrasting evidence that she is worse when playing with Kai'Sa.
Moreover, when Cassiopeia plays with Kai'Sa on the same team, she usually takes a little less damage than when she plays alone. Receiving not as much damage may indicate that Kai'Sa does a decent job of covering Cassiopeia during teamfights.
There is no top companion for Cassiopeia that will always be her #1 ally. Yet, overall, Kai'Sa is a relatively poor companion for Cassiopeia. By locking into the same side as Cassiopeia, she lowers their win rate by -3.0% to 47.3%. This clearly indicates that there is a harmful bond between Cassiopeia and Kai'Sa that results in them performing not as well together than alone.
Kai'Sa has a much lower diffuclty than Cassiopeia. That means you don't need to be careful when finding Kai'Sa allies to play with, as they will need a much lower level of skill to cooperate well with you.
Working on the same side, Cassiopeia players should see an overall large increase in your team’s ability to deal magical damage. Together, these champs can deal quite a lot of AP type damage.
In contrast, by grouping Cassiopeia and Kai'Sa together, you may not be providing your team a lot of support. Plan to include other champions on your team that helps cover this relative gap in this pairing's capabilities.
Regardless of your Kai'Sa ally's ability, you need to focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you will do well anyway.
To learn all of the intricacies of Cassiopeia in order to work well with Kai'Sa during both the lane and mid / late game phases of League of Legends, you should keep reading to gather additional lessons on this champion pairing. If you listen to the build and stats displayed above, you should grow your win rate significantly.
The most crucial finished items to build first in your Cassiopeia and Kai'Sa synergy build include Rylai's Crystal Scepter, Liandry's Torment, and Rod of Ages. When Cassiopeia used at least these three pieces in her build, she did a lot better when fighting alongside Kai'Sa than with most other common builds. In fact, Cassiopeia had an average winrate of 47.3% when playing alongside Kai'Sa with these items in her kit.
To have the best probability of defeating your oponents, Cassiopeia players should take the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Of all the runes players picked for this team composition, this order of runes yielded the highest win rate. Notably, these runes gave a 47.3% win rate overall.
If you need to see Cassiopeia and Kai'Sa collaboration tips and stats for a a distinct player tier, feel free to choose one from the selection menu shown above. If viewing for the first time, the stats and build suggestions shown are calculated using all matches played with these champs.