Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Cassiopeia Annie synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Annie, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA decreased from NaN to NaN. This negative change shows that Annie helps Cassiopeia perform poorer in competitive League of Legends matches. Yet, the small difference proves that this performance change is not very impactful.
When Cassiopeia is paired with Annie, she observes a little decrease in her total damage dealt. This may signal that Annie does not help protection for her to deal more damage or that her participation also helps increase the round's duration. Similarly, when Cassiopeia is played alongside Annie on the same team, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Annie.
Additionally, when Cassiopeia plays with Annie on the same team, she usually takes a little more damage than when she fights alone. Receiving more damage could indicate that Annie does a poor job of covering Cassiopeia in team fights.
There is no ideal companion for Cassiopeia that will no matter what be her ideal ally. Yet, Annie is a very typical teammate for Cassiopeia. By locking into the same side as Cassiopeia, she decreases their win rate by -0.3% to 50.0%. This clearly indicates that there is only a small synergy between Cassiopeia and Annie that results in them performing not as well together than without each other.
Annie has a much lower diffuclty than Cassiopeia. That means Cassiopeia players don't need to be cautious when lining up Annie allies to play with, as they will need a much lower level of skill to be able to cooperate well with you.
Fighting alongside, Cassiopeia players should see an overall large increase in your team’s capacity to deal magical damage. When paired, these champions can blast through enemies with magic damage.
Although, by aligning Cassiopeia and Annie together, you may not be providing your team a great deal of AD. Plan to pick other champs on your team that neutralizes this relative gap in this pairing's kit.
Regardless of your Annie ally's skill level, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
To learn all of the intricacies of Cassiopeia to work well with Annie during both the laning and mid / late game phases of League rounds, you should keep reading to master a few extra lessons on this champion pairing. If you use the build and stats shown above, you should increase your win rate by a lot.
The top finished items to build first in your Cassiopeia and Annie synergy build consist of Seraph's Embrace, Rylai's Crystal Scepter, and Rod of Ages. When Cassiopeia bought at least these three great items in her build, she performed a lot better when paired up with Annie than with many other commonly used item sets. In fact, Cassiopeia had an average winrate of 50.0% helping carry Annie with these items in her kit.
To have the highest probability of vanquishing your oponents, you should equip the Conqueror, Presence of Mind, Legend: Tenacity, Last Stand, Manaflow Band, and Transcendence runes from the Precision and Sorcery rune sets. Out of all the rune combinations players chose for Cassiopeia and Annie pairings, this blending of runes yielded the top win rate. In fact, these runes averaged a 50.0% winrate overall.
By default, tips, stats, and builds on how to synergize Annie with Cassiopeia are presented for all skill levels combined. To scope the stats and builds to a distinct rank, you can use the selection menu earlier in the counter matchup guide.