Fire 90 Caliber Net away from the opponent to close the gap or hop over walls.
Avoid using Ace in the Hole in large team melees as it might be blocked by the wrong target.
Make use of her Yordle Snap Traps by placing them pre-emptively to ensure that you'll have one off of cooldown during combat.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Caitlyn Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Caitlyn sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This negative change shows that Karthus helps Caitlyn perform worse in ranked League of Legends rounds. Yet, the small difference proves that this performance change is only marginal.
When Caitlyn plays on the same team as Karthus, she gets a marginal improvement in her total damage dealt. This could indicate that Karthus supports by providing cover for her to deal more damage or that his presence also helps increase the match's duration. Similarly, when Caitlyn is played alongside Karthus on the same team, he usually scores many fewer killing sprees than when she plays without Karthus. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Additionally, when Caitlyn plays with Karthus on the same team, she on average takes more damage than when she fights alone. Taking more damage may indicate that Karthus does a poor job of protecting Caitlyn during teamfights.
There is no universally accepted best champion pairing for Caitlyn that will 100% of the time be her ideal ally. However, overall, Karthus is a relatively poor companion for Caitlyn. By playing on the same side as Caitlyn, he drops their win rate by -1.9% to 47.4%. This clearly indicates that there is a harmful synergy between Caitlyn and Karthus that results in them performing not as well together than alone.
Karthus has a greater difficulty than Caitlyn. That means Caitlyn players need to be cautious when lining up Karthus allies to go into battle on the same side as, as they will have to have a greater level of skill to be able to work well with you.
Playing on the same side, you should observe an overall large increase in your team’s capability to to do a lot of AP damage. When paired, these two are able to dish out a surprising amount of magic type damage.
Conversely, by grouping Caitlyn and Karthus together, you may not be giving your other teammates a great deal of protection for burst damage. We recommend you have other champs on your team that neutralizes this relative hole in their playstyle.
Regardless of the ability of your Karthus ally, you should focus on increasing your gold income, outlasting your enemies, and taking down objectives. If you do this, you should do well anyway.
To truly master Caitlyn in order to work well with Karthus during both the early game and mid / late game phases of LoL games, you should continue reading to master additional tips and tricks for this champion pairing. If you use the build and suggestions presented here, you will grow your win rate by a lot.
The top finished items to use in your Caitlyn and Karthus synergy build consist of Infinity Edge, Bloodthirster, and Rapid Firecannon. When Caitlyn used at least these three great items in her build, she did significantly better when fighting alongside Karthus than with most other commonly used item sets. In fact, Caitlyn had an average winrate of 47.4% helping carry Karthus with these items in her kit.
To have the highest chance of coming out on top against your oponents, you should use the Fleet Footwork, Presence of Mind, Legend: Bloodline, Coup de Grace, Absolute Focus, and Gathering Storm runes from the Precision and Sorcery rune sets. Out of all the runes players picked for this team composition, this set of runes resulted in the top win rate. Moreover, these runes averaged a 47.4% winrate overall.
By default, tips, stats, and builds on how to team up Karthus with Caitlyn are given for all ranked divisions. To narrow the statistics and builds to a particular division, you should use the selection menu located above.