You can use Brand's abilities in a variety of combinations to maximize his damage in different situations.
You can deter enemies from standing near their minions by setting them ablaze, due to Conflagration.
Pyroclasm bounces randomly between enemies, so try to cast it on a small group of enemies if you want to hit the same target multiple times.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Brand Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Brand sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This fall shows that Karthus helps Brand perform not as well in ranked LoL games. Yet, the small difference shows that this performance change is only marginal.
When Brand tries to synergize with Karthus, he observes a little decrease in his complete damage dealt. This difference may demonstrate that Karthus does not support by providing cover for him to dish out more damage or that his presence on the team also helps extend the round's duration. Similarly, when Brand is played with Karthus on the same team, he usually scores many fewer killing sprees compared to when he plays without Karthus. This is contrasting evidence that he is worse when playing with Karthus.
Additionally, when Brand plays with Karthus on the same team, he typically takes a little less damage than when he plays alone. Receiving not as much damage could mean that Karthus does a decent job of protecting Brand in team fights.
There is no ideal ally for Brand that will 100% of the time be his #1 synergy. However, Karthus is a terrible companion for Brand. By being on the same team as Brand, he lowers their win rate by -5.7% to 45.7%. This clearly indicates that there is an easy to overcome and exploit bond between Brand and Karthus that results in them performing worse together than without each other.
Karthus has a greater difficulty than Brand. That means you should be careful when lining up Karthus teammates to go into battle on the same side as, as they will require a greater level of skill to be able to cooperate well with you.
When playing on the same side, you should witness an overall large increase in your team’s capacity to to do a lot of AP damage. Together, these champions can deal quite a lot of AP type damage.
Conversely, by grouping Brand and Karthus together, you may not be providing your other allies a great deal of attack damage. Make sure to pick other champions on your team that nullifies this relative disparity in this pairing's abilities.
Regardless of your Karthus ally's skill level, you need to focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well anyway.
To learn all of the intricacies of Brand in order to work well with Karthus during both the laning and mid / late game phases of League rounds, you should continue reading to pick up additional tips and tricks for this champion pairing. If you mind the build and tips presented above, you should increase your win rate significantly.
The most crucial items to focus on in your Brand and Karthus synergy build consist of Rylai's Crystal Scepter, Morellonomicon, and Liandry's Torment. When Brand combined at least these three great items in his build, he performed significantly better when paired up with Karthus than with most other common item sets. In fact, Brand boasted an average winrate of 45.7% when playing alongside Karthus with these items in his kit.
To have the highest probability of annihilating your oponents, Brand players should use the Dark Harvest, Taste of Blood, Eyeball Collection, Ultimate Hunter, Coup de Grace, and Presence of Mind runes from the Domination and Precision rune sets. Out of all the rune combinations players picked for this champion pairing, this combination of runes resulted in the best win rate. Notably, these runes averaged a 45.7% win rate overall.
By default, tips, statistics, and builds on how to synergize Karthus with Brand are presented for all skill levels, merged. To scope the statistics and builds to a particular player tier, you may use the selection menu located at the top of this page.