Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Annie Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA fell from NaN to NaN. This decrease shows that Vayne helps Annie perform worse in competitive LoL rounds. Yet, the small difference indicates that this performance change is not very impactful.
When Annie plays on the same team as Vayne, she gets a marginal improvement in her complete damage output. This change could demonstrate that Vayne provides protection for her to dish out more damage or that her presence also helps increase the round's duration. Similarly, when Annie is played with Vayne on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing with Vayne.
Moreover, when Annie plays with Vayne on the same side, she usually receives a little less damage than when she fights alone. Getting dealt not as much damage may indicate that Vayne does a decent job of covering Annie in teamfights.
There is no perfect companion for Annie that will always be her top teammate. However, overall, Vayne is a very typical ally for Annie. By playing on the same team as Annie, she increases their win rate by 0.8% to 50.1%. This clearly indicates that there is a weak bond between Annie and Vayne that results in them performing at the top of their game together than alone.
Vayne has a greater difficulty than Annie. That means Annie players must be very careful when enlisting Vayne allies to fight alongside, as they will need a greater level of skill to be able to fight well with you.
When playing together, Annie players should witness an overall large increase in your team’s capacity to dish out massive AD. Together, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
In contrast, by pairing Annie and Vayne together, you may not be providing your side enough engage potential. Make sure to have other champions on your team that helps cover this relative hole in this pairing's abilities.
Regardless of your Vayne ally's ability, you need to focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well, regardless.
To truly master Annie in order to work well with Vayne during both the early game and mid / late game phases of LoL, you should continue reading to master some more tricks and insights into this champion pairing. If you listen to the build and tips shown above, you will increase your win rate by a lot.
The most important finished items to get in your Annie and Vayne synergy build include Rabadon's Deathcap, Malignance, and Stormsurge. When Annie incorporated at least these three items in her build, she did a lot better when fighting alongside Vayne than with most other common builds. In fact, Annie had an average winrate of 50.1% when synergizing her build and playstyle to Vayne with this build.
To have the best probability of vanquishing your oponents, Annie players should take the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Manaflow Band, and Absolute Focus runes from the Domination and Sorcery rune sets. Out of all the runes we have analyed for this champion pairing, this combo of runes resulted in the top win rate. In fact, these runes gave a 50.1% winrate overall.
By default, tips, statistics, and builds on how to pair Vayne with Annie are presented for every ranked division. If you would like to narrow the statistics and builds to an individual division, you should use the selection menu located at the top of this page.