Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
The Annie Neeko synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Neeko, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Neeko. His KDA went down from NaN to NaN. This fall shows that Neeko helps Annie perform not as well in competitive League games. Yet, the small difference indicates that this performance change is not very impactful.
When Annie tries to synergize with Neeko, she sees a small decrease in her full damage output. This change may demonstrate that Neeko does not provide cover for her to deal more damage or that her support also helps extend the game's duration. Similarly, when Annie is played alongside Neeko on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing alongside Neeko.
Additionally, when Annie plays with Neeko on the same team, she typically receives a little more damage than when she fights alone. Receiving more damage could mean that Neeko does a poor job of covering Annie during teamfights.
There is no universally accepted best champion pairing for Annie that will 100% of the time be her top teammate. However, Neeko is a below average companion for Annie. By locking into the same side as Annie, she lowers their win rate by -2.7% to 46.6%. This clearly indicates that there is a harmful bond between Annie and Neeko that results in them performing not as well together than without each other.
Neeko has a lower difficulty than Annie. That means you don't need to be careful when finding Neeko allies to play with, as they will need a relatively low level of skill to do well with you.
Fighting cooperatively, Annie players should witness an overall large increase in your team’s capability to deal magic damage. Together, these champions can blast through enemies with magic damage.
In contrast, by grouping Annie and Neeko together, you may not be granting your other allies very much attack damage. Make sure to include other champs on your team that offsets this hole in their capabilities.
Regardless of your Neeko ally's skill level, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
If you would like to truly master Annie in order to work well with Neeko during both the early game and mid / late game phases of LoL, you should keep reading to gather some more tricks and insights into this champion pairing. If you listen to the build and suggestions shown here, you will increase your win rate significantly.
The top items to focus on in your Annie and Neeko synergy build include Rabadon's Deathcap, Shadowflame, and Stormsurge. When Annie bought at least these three finished items in her build, she did significantly better when fighting alongside Neeko than with most other common item sets. In fact, Annie had an average winrate of 46.6% helping carry Neeko with these items in her kit.
To have the highest likelihood of annihilating your oponents, you should use the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Absolute Focus, and Manaflow Band runes from the Domination and Sorcery rune sets. Out of all the rune builds players used for this team composition, this mixture of runes resulted in the highest win rate. Notably, these runes provided a 46.6% win rate overall.
If you need to view Annie with Neeko collaboration tips and builds for a a particular rank, feel free to choose one from the selection menu shown above. At first, the statistics and tips and suggestions given are computed using all matches played with both champs.