Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Annie Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA fell from NaN to NaN. This fall shows that Karthus helps Annie perform poorer in competitive League of Legends matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Annie is an ally to Karthus, she gets a little drop in her full damage output. This change could signal that Karthus does not provide cover for her to deal more damage or that his participation also helps increase the round's duration. Similarly, when Annie is played together with Karthus on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Additionally, when Annie plays with Karthus on the same side, she on average takes more damage than when she fights alone. Getting dealt more damage could mean that Karthus does a poor job of covering Annie in teamfights.
There is no top companion for Annie that will 100% of the time be her ideal synergy. Yet, Karthus is a not very good teammate for Annie. By playing on the same side as Annie, he decreases their win rate by -1.2% to 48.1%. This clearly indicates that there is a bad strategic relationship between Annie and Karthus that results in them performing not as well together than alone.
Karthus has a greater difficulty than Annie. That means you must be very careful when finding Karthus comrades to play with, as they will require a greater level of skill to fight well with you.
Playing cooperatively, Annie players will likely witness an overall large increase in your team’s ability to deal magic damage. Combined, these two can deal quite a lot of AP type damage.
Conversely, by bringing Annie and Karthus together, you will not be providing your side much attack damage. We recommend you include other champions on your team that helps cover this relative disparity in their potential.
Regardless of the skill of your Karthus teammate, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to truly master Annie in order to synergize with Karthus during both the early game and mid / late game phases of LoL, you should keep reading to gather additional tips and tricks for this champion pairing. If you use the build and stats displayed here, you will grow your win rate by a lot.
The ideal finished items to include in your Annie and Karthus synergy build include Malignance, Shadowflame, and Stormsurge. When Annie included at least these three pieces in her build, she did much better when paired up with Karthus than with most other common builds. In fact, Annie had an average winrate of 48.1% when synergizing her build and playstyle to Karthus with these items in her kit.
To have the greatest probability of crushing your oponents, you should use the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Absolute Focus, and Manaflow Band runes from the Domination and Sorcery rune sets. Of all the runes we have analyed for this team composition, this sequence of runes resulted in the top win rate. Notably, these runes gave a 48.1% winrate overall.
If you would like to view Annie with Karthus synergy tips and stats for a a specific skill level, feel free to choose one from the selection menu displayed above. At first, the stats and guides displayed are computed using every match completed with these champs.