Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Annie Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This fall shows that Cassiopeia helps Annie perform worse in competitive LoL rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Annie plays on the same team as Cassiopeia, she observes a moderate decrease in her total damage dealt. This change could indicate that Cassiopeia doesn't help cover for her to dish out more damage or that her support also helps increase the game's duration. Similarly, when Annie is played together with Cassiopeia on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing alongside Cassiopeia.
Additionally, when Annie plays with Cassiopeia on the same side, she often takes a little less damage than when she plays alone. Receiving not as much damage could indicate that Cassiopeia does a decent job of covering Annie in teamfights.
There is no top synergy for Annie that will 100% of the time be her #1 teammate. Yet, overall, Cassiopeia is a very typical teammate for Annie. By locking into the same side as Annie, she increases their win rate by 0.7% to 50.0%. This demonstrates that there is not really a strong synergy between Annie and Cassiopeia that allows them to perform better together than alone.
Cassiopeia has a much greater difficulty compared to Annie. That means Annie players need to be careful when lining up Cassiopeia comrades to go into battle on the same side as, as they will require a much higher level of skill to be able to work well with you.
Fighting on the same side, you will likely witness an overall large increase in your team’s capacity to deal magic damage. Combined, these two can blast through enemies with magic damage.
Although, by aligning Annie and Cassiopeia together, you probably will not be giving your side a lot of AD. Plan to include other champs on your team that fills this relative disparity in their capabilities.
Regardless of the ability of your Cassiopeia teammate, you need to focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you should do well, regardless.
To learn all of the intricacies of Annie to synergize with Cassiopeia during both the early game and mid / late game phases of League of Legends rounds, you should continue reading to pick up additional tricks and insights into this champion pairing. If you pay attention to the build and suggestions shown here, you will grow your win rate by a lot.
The most crucial items to include in your Annie and Cassiopeia synergy build consist of Rabadon's Deathcap, Malignance, and Liandry's Torment. When Annie used at least these three finished items in her build, she did significantly better when paired up with Cassiopeia than with many other typical builds. In fact, Annie boasted an average win rate of 50.0% when synergizing her build and playstyle to Cassiopeia with these items in her kit.
To have the best likelihood of crushing your oponents, Annie players should use the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Absolute Focus, and Manaflow Band runes from the Domination and Sorcery rune sets. Out of all the rune builds players picked for this team composition, this set of runes resulted in the greatest win rate. In fact, these runes provided a 50.0% win rate overall.
By default, tips, statistics, and builds on how to team up Cassiopeia with Annie are presented for every ranked division. To scope the statistics and builds to a specific rank, you may use the selection menu located earlier in the counter matchup guide.