Timing Flash Frost with Frostbite can lead to devastating combinations.
It can be very difficult for enemy champions to kill her egg early in game. Seize the advantage by playing aggressively.
Anivia is extremely reliant on Mana for Glacial Storm. Try getting items with Mana or going for a Crest of the Ancient Golem buff on Summoner's Rift.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Anivia Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Anivia sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA fell from NaN to NaN. This drop shows that Karthus helps Anivia perform worse in competitive League of Legends matches. Yet, the small difference indicates that this performance change is only marginal.
When Anivia is paired with Karthus, she sees a small decrease in her total damage dealt. This change could indicate that Karthus does not provide protection for her to deal more damage or that his support also helps increase the game's duration. Similarly, when Anivia is played together with Karthus on the same team, he usually scores many fewer killing sprees than when she plays without Karthus. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Additionally, when Anivia plays with Karthus on the same team, she on average receives more damage than when she plays alone. Getting dealt more damage could indicate that Karthus does a poor job of covering Anivia during team fights.
There is no top champion pairing for Anivia that will no matter what be her #1 teammate. Yet, Karthus is a terrible teammate for Anivia. By locking into the same team as Anivia, he decreases their win rate by -6.0% to 44.9%. This signals that there is a terrible synergy between Anivia and Karthus that results in them performing not as well together than alone.
Karthus has a much lower diffuclty than Anivia. That means you don't need to be careful when arranging Karthus comrades to go into battle on the same side as, as they will have to have a much lower level of skill to do well with you.
Playing on the same side, you should expect to see an overall large increase in your team’s ability to deal magic damage. Together, these champions can blast through enemies with magic damage.
Conversely, by grouping Anivia and Karthus together, you will not be granting your side much AD. Plan to have other champions on your team that neutralizes this hole in this pairing's capabilities.
Regardless of the ability of your Karthus ally, you need to focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you will do well anyway.
To truly master Anivia in order to pair well with Karthus during both the laning and mid / late game phases of League matches, you should keep reading to pick up additional lessons on this champion pairing. If you listen to the build and stats shown here, you should increase your win rate significantly.
The ideal items to have in your Anivia and Karthus synergy build include Seraph's Embrace, Liandry's Torment, and Rod of Ages. When Anivia used at least these three items in her build, she did a lot better when fighting alongside Karthus than with many other common item sets. In fact, Anivia boasted an average winrate of 44.9% when synergizing her build and playstyle to Karthus with these items in her kit.
To have the highest chance of annihilating your oponents, Anivia players should take the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Presence of Mind, and Coup de Grace runes from the Domination and Precision rune sets. Out of all the rune sets players used for Anivia and Karthus pairings, this mixture of runes resulted in the best win rate. Notably, these runes gave a 44.9% winrate overall.
If you need to get Anivia with Karthus synergy tips and stats for a a specific division rank, feel free to select one from the selection menu shown above. If viewing for the first time, the stats and guides displayed are calculated using all matches run with both champs.