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The Karthus Seraphine synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Seraphine, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Seraphine. His KDA decreased from NaN to NaN. This drop shows that Seraphine helps Karthus perform poorer in competitive League rounds. Yet, the small difference indicates that this performance change is only marginal.
When Karthus tries to synergize with Seraphine, he gets a small increase in his full damage dealt. This difference may indicate that Seraphine provides cover for him to deal more damage or that her allyship also helps increase the game's duration. Similarly, when Karthus is played with Seraphine on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing with Seraphine.
Moreover, when Karthus plays with Seraphine on the same side, he on average takes a little more damage than when he plays alone. Getting dealt more damage may mean that Seraphine does a poor job of covering Karthus during team fights.
There is no one best champion pairing for Karthus that will always be his ideal ally. However, overall, Seraphine is a very typical ally for Karthus. By being on the same side as Karthus, she lowers their win rate by -0.8% to 46.5%. This shows that there is not really a strong bond between Karthus and Seraphine that results in them performing not as well together than without each other.
Seraphine has a much lower diffuclty than Karthus. That means Karthus players don't need to be careful when arranging Seraphine teammates to play with, as they will require a much lower level of skill to work well with you.
Fighting on the same side, you should see an overall large increase in your team’s capability to support your allies. Together, these champions should be able to manipulate the pace of team fights.
Although, by bringing Karthus and Seraphine together, you will not be granting your other allies enough sustained damage output. Make sure to pick other champs on your team that neutralizes this relative hole in their playstyle.
Regardless of your Seraphine ally's ability, you should focus on increasing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you do this, you will do well, regardless.
To learn all of the intricacies of Karthus to synergize with Seraphine during both the lane and mid / late game phases of League of Legends, you should continue reading to master a few extra lessons on this champion pairing. If you listen to the build and stats displayed here, you will grow your win rate by a lot.
The best finished items to prioritize in your Karthus and Seraphine synergy build consist of Malevolência, Cajado do Vazio, and Chama Sombria. When Karthus incorporated at least these three great items in his build, he did a lot better as an ally of Seraphine than with many other commonly used builds. In fact, Karthus had an average win rate of 46.5% when playing alongside Seraphine with this build.
To have the highest chance of coming out on top against your oponents, you should take the Colheita Sombria, Golpe Desleal, Globos Oculares, Caça Suprema, Tempestade Crescente, and Transcendência runes from the Dominação and Feitiçaria rune sets. Of all the rune combinations players chose for this team composition, this combination of runes yielded the highest win rate. In fact, these runes provided a 46.5% winrate overall.
By default, tips, statistics, and builds on how to synergize Seraphine with Karthus are given for all ranked divisions combined. To filter the statistics and builds to a particular skill level, you can use the selection menu located earlier on the page.